Oily Skin Clinical Trial
Official title:
Pilot Randomized Double-Blind Controlled Trial of Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin
This is a randomized double-blinded study examining the effect of topical Acetyl Hexapeptide-8 AH8) for improving the cosmetic appearance and experience of oily skin.
The purpose of this randomized double-blinded study is to investigate whether topical Acetyl
Hexapeptide-8 can improve oily skin. Up to 15 adult subjects will be recruited. Each half of
the face will randomized to receive either topical treatment with AH8 10% Lotion formulated
in Cetaphil® Moisturizing Facial Lotion or the placebo vehicle treatment consisting of
Cetaphil® Moisturizing Facial Lotion only, at twice daily application for 4 weeks.
The study consists of a total of 3 sessions: baseline visit, and at 2 weeks and 4 weeks for
follow up assessment. Subjects will also be asked to complete an Oily Skin Self-Assessment
Scale (OSSAS) and an Oily Skin Impact Scale (OSIS) survey at the first session. They will be
filling out two OSSAS surveys (one for each side of the face) at the second and third
sessions. The OSSAS survey includes subjective assessment of four components of oily skin:
visual, blotting, tactile, and sensation. At each visit, the cosmetic appearance the facial
skin will be scored clinically by a dermatologist using a validated 3-point scale for shine
(1 = high, 2, moderate or 3 = low), and oiliness (1 = normal, 2 = easily visible or 3 =
extensive) 16. High-resolution digital photographs of the facial skin with the use of
photography and facial analysis instrumentation will be taken at baseline and at each visit
to document facial appearance and for image analysis of shine level. Sebum of the left and
right cheeks will be measured by a sebumeter to correlate to the oily appearance noted on
the high resolution facial photographs.
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