Ocular Physiology Clinical Trial
Official title:
Is There a Difference in Flicker Induced Vasodilatation Between Smokers and Non-Smokers?
Habitual smoking is associated with an increased risk of coronary artery disease, cerebral
and peripheral vascular disease, including ocular diseases like age-related macular
degeneration or diabetic retinopathy. Data of a recent study performed in the investigators
lab revealed abnormal choroidal blood flow regulation in chronic smokers as compared to
age-matched non-smoking subjects during isometric exercise. However, no information is yet
available about the regulation of retinal vascular tone in habitual smokers.
Thus, in the current study, the investigators set out to investigate whether the regulation
of retinal vessels diameters is affected in habitual smokers. It has been shown in several
reports that stimulation with diffuse luminance flicker, increases retinal arterial and
venous diameters, indicating for the ability of the retina to adapt to changing metabolic
demands. In the current study we use this effect as a tool to investigate whether the
flicker induced vasodilatation is affected in habitual smokers. This would indicate for an
impaired vascular regulation process in smokers.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00431392 -
Mechanisms of Choroidal Blood Flow Changes During Dark/Light Transitions
|
Phase 2 | |
Completed |
NCT06161012 -
Evaluation of Delefilcon A and Senofilcon A Daily Disposable Toric Soft Contact Lenses Over Two Weeks of Wear
|
N/A | |
Terminated |
NCT00708357 -
Does eNOS Gene Polymorphism Play a Role in the Maintenance of Basal Vascular Tone in the Choroid or Optic Nerve Head?
|
Phase 0 | |
Completed |
NCT05291936 -
Clinical Evaluation of Two Daily Disposable Toric Soft Contact Lenses Over One Week of Wear
|
N/A | |
Withdrawn |
NCT00712777 -
Relation Between Intraocular Pressure Lowering Effects of Topical Brimonidine and Alpha 2 Receptor Polymorphism
|
N/A | |
Completed |
NCT00709423 -
Effects of Moxaverine and Placebo on Ocular Blood Flow
|
Phase 2 | |
Completed |
NCT00708929 -
Does Complement Factor H Gene Polymorphism Play a Role in the Regulation of Vascular Tone in the Choroid?
|
N/A | |
Completed |
NCT00712400 -
Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects
|
N/A | |
Completed |
NCT01663688 -
Data Collection Study of the Nidek Optical Coherence Tomography RS-3000 for 3D Measurements of the Eye
|
N/A | |
Completed |
NCT05427539 -
Feasibility Evaluation of Daily Disposable Toric Soft Contact Lenses Manufactured With an Alternative Hydration Process
|
N/A | |
Completed |
NCT05713552 -
Evaluation of ACUVUE® OASYS 1-Day for Astigmatism Contact Lenses With Alternative Lidstock
|
N/A | |
Withdrawn |
NCT00406731 -
Role of Endothelin- and Nitric Oxide-system in the Regulation of Optic Nerve Head Blood Flow During Changes in Ocular Perfusion Pressure
|
Phase 2 | |
Completed |
NCT00706927 -
Effect of Xalacom® (Latanoprost/Timolol) and Combigan® (Brimonidine/Timolol) Fixed Combination on Intraocular Pressure and Ocular Blood Flow in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
|
N/A | |
Completed |
NCT00275730 -
Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers
|
N/A | |
Completed |
NCT00712764 -
Role of Adenosine in the Control of Choroidal Blood Flow During Changes in Ocular Perfusion Pressure.
|
N/A | |
Withdrawn |
NCT05530889 -
Evaluating Quality of Life Benefits of ACUVUE® Theravision® With Ketotifen in Subjects With Ocular Allergies
|
N/A | |
Completed |
NCT00312416 -
Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise
|
Phase 4 | |
Completed |
NCT00712907 -
Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow
|
N/A | |
Withdrawn |
NCT00991900 -
Short Term and Day to Day Reproducibility of Reflectometric Measurement of Retinal Oxygen Saturation in Healthy Subjects
|
||
Completed |
NCT00280462 -
Choroidal Blood Flow Regulation During Isometric Exercise: Effects of Ca2+-Channel Blockade
|
N/A |