Obstructive Sleep Apnoea Clinical Trial
Official title:
Minimum Effective Dose-Finding Study of BF2.649, in Patients With Moderate to Severe OSA, Experiencing EDS Despite Regular Use of nCPAP, and Patients Having Refused This Therapy - Randomized, Double Blind Study With BF2.649 or Placebo
Prospective, multicenter, double-blind, phase II, randomized, dose-response study in 5 parallel groups (dose-range).
Obstructive sleep apnea (OSA) is a relatively common condition and is estimated to affect 2
to 4% of middle-aged adults
The study medication BF2.649 tested here is a novel, highly potent, selective, orally active
inverse agonist at the histamine H3 receptor, therefore strengthens histaminergic
transmission in the brain and increases wakefulness EDS is characterized by daytime
somnolence and sudden sleep episodes. This problem has several consequences, e.g., an
impairment of quality of life, an interference with activities of daily living and other
handicaps in the management of social and family affairs.
The primary endpoint of this study will be measured by the change in the well-validated
Epworth sleepiness scale (ESS). The ESS is a simple self-administered 8-item questionnaire.
The outcome is to get an impression about the level of the daytime sleepiness in several
real-life situations.
In this study, each patient will be treated during 2 weeks, and randomly assigned to one the
5 arms (BF2.649 at one of the 4 possible dosages or placebo).
The patient will then attend a end-of-treatment visit, in order to assess the particularly
the ESS score.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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