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Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea

Obstructive Sleep Apnea of Adult Clinical Trial

Official title:
Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea

Clinical Trial Summary

This study will recruit 66 patients with obstructive sleep apnea, comprising 33 men and 33 women, who have been referred to the sleep center by their doctors for polysomnograms (PSG). The subjects will undergo two overnight sleep PSG sessions at the sleep center. The interval between the two examinations will be at least 7 days, during which they will receive both a placebo and medication conditions, administered 1 hour before bedtime. The study drugs will include: (1) atomoxetine 80 mg and oxybutynin 5 mg; or (2) venlafaxine 37.5 mg; or (3) atomoxetine 80 mg and trazodone 100 mg. Endotypic traits will be estimated using the Phenotyping Using Polysomnography method. The primary outcome is the change in apnea-hypopnea index, and secondary outcomes include endotypic traits and sleep parameters.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06295562
Study type Interventional
Source China Medical University Hospital
Contact Cheng, Ph.D.
Phone +886422052121
Email s871065@gmail.com
Status Not yet recruiting
Phase Phase 1
Start date April 1, 2024
Completion date July 31, 2025
View Details
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