Effect of Inspiratory Muscle Training in Obstructive Sleep Apnea Syndrome. — NOCTURNE  

Obstructive Sleep Apnea of Adult Clinical Trial

Official title: Effect of Inspiratory Muscle Training on Daytime Sleepiness in Obstructive Sleep Apnea Syndrome : Prospective Randomized Controlled Trial

Status Not yet recruiting

Clinical Trial Summary

Sleep apnea-hypopnea syndrome is a sleep-related respiratory disorder characterized by partial or total interruptions in breathing during sleep. The majority of syndromes involve an obstructive mechanism (OSA), caused by a reduction in the caliber of the upper airway (UA), most often associated with hypotonia of the surrounding muscles, preventing air from entering the UA during inspiration (1). The clinical consequences of this syndrome are excessive fatigue and daytime sleepiness, which have a negative impact on the quality of life of patients. (2,3) Despite the positive results on apnea-hypopnea index and daytime sleepiness of continuous positive airway pressure (today's reference treatment), its 3-year compliance rate (i.e 59.9% according to a study by Abdelghani et al (4) points to the need to develop other associated therapies.

Several studies have demonstrated the efficacy of physiotherapy, such as physical activity and oro-pharyngeal muscle strengthening, notably on the apnea-hypopnea index and daytime sleepiness measured by the Epworth scale (5,6).

Few studies have investigated the effect of inspiratory muscle training (IMT), even though the use of the inspiratory musculature (i.e. the diaphragm) is a means of supplementing the peri-pharyngeal muscles, as it helps to maintain the permeability of the upper airways (7-9). Inspiratory muscle training (IMT) could therefore be considered as part of the physiotherapeutic management of the OSA. The heterogeneity of current results concerning IMT in OSA , but above all the lack of evidence that it is dangerous, means that new clinical studies could be carried out in an attempt to demonstrate its efficacy. Our research hypothesis is therefore as follows: Implementing an inspiratory muscle strengthening protocol in patients suffering from OSA can reduce daytime sleepiness.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Apnea
• Obstructive Sleep Apnea of Adult
• Respiratory Aspiration
• Sleep Apnea Syndromes
• Sleep Apnea, Obstructive

• NCT number: NCT06117579
• Study type: Interventional
• Source: Centre Hospitalier Régional d'Orléans
• Contact: Aurelie DESPUJOLS, Msc
• Phone: +332 38 74 40 71
• Email: aurelie.despujols@chu-orleans.fr
• Status: Not yet recruiting
• Phase: N/A
• Start date: June 2024
• Completion date: January 1, 2026