Clinical Trials Logo
  1. Home
  2. Obstructive Pulmonary Disease
  3. NCT05028985

Early COPD for China Pulmonary Health Study Stage II — EC-CPHS  

Obstructive Pulmonary Disease Clinical Trial

Official title:
A Cohort Study of Early Chronic Obstructive Pulmonary Disease for China Pulmonary Health Study Stage II

Clinical Trial Summary

Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease

Clinical Trial Description

This project is aimed to investigate and explore the heterogeneity during the progression of Chronic Obstructive Pulmonary Disease (COPD) in the early stage, utilizing the large-scale population cohort databases (including "China Pulmonary Health study", "The Cohort Study for Chronic Obstructive Pulmonary Disease in China" and "Acute Exacerbation of COPD Patient Registry in China" ), biological sample libraries(including blood, sputum, expiratory air, bronchoalveolar lavage fluid(BALF), and lung tissue from COPD patients with different stages and phenotypes), and multi-omics sequencing (including scRNA-seq, metabolomics, proteomics, and metagenome). We propose to establish a new standard for COPD stages and subtypes. By analyzing and mining the multi-omics data, it is expected to illustrate the association between clinical phenotype and molecular, cellular and tissue heterogeneities, thus reveal biomarkers related to the progression, clinical phenotypes, and prognosis of early-stage COPD disease.In addition, we will construct different types and stages of COPD animal models for further mechanism studies, such as the different pathogenic factors, innate and adaptive immunity, and the airway microbial ecosystem, so that we can discovered more potential therapeutic target for early-stage COPD. This project can bring a new insight and scientific evidence for COPD treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05028985
Study type Observational
Source China-Japan Friendship Hospital
Contact Chen Wang
Phone +86 010 69156477
Email cyh-birm@263.net
Status Recruiting
Phase
Start date January 1, 2021
Completion date December 2025
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT05250128 - The Significance of Circulating Microvesicles in Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease
Completed NCT04748900 - Physiotherapy Treatment Plan in Allergic Bronchopulmonary Aspergillosis: Case Report
Recruiting NCT06149494 - RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection Phase 2
Active, not recruiting NCT04668599 - Cardio-pulmonary Rehabilitation and Sleep Quality
Recruiting NCT04020081 - A Study to Evaluate the Effect of Yoga Exercises and Meditation on Lung Function and Quality of Life in COPD Patients. N/A
Completed NCT04048408 - Comparison of Respiratory Muscle, Pain, Functional Performance and Cognitive Status in Obstructive Lung Diseases
Completed NCT04136951 - Improving Patient Prioritization During Hospital-homecare Transition N/A
Not yet recruiting NCT02283008 - Inhaler Technique Training N/A
Recruiting NCT04050943 - A Cohort of Patients With Chronic Pulmonary Disease
Recruiting NCT03888300 - Measurement of Viscoelastic Properties of Bronchopulmonary Secretions. N/A
Completed NCT04820556 - Gut Microbiota in Chronic Noncommunicable Diseases
Recruiting NCT05654597 - French Validation of the CAPTURE Case Finding Tool for Obstructive Respiratory Disease