Obstructive Hydrocephalus Clinical Trial
Official title:
Hypothalamic-pituitary Effects After Endoscopic Third Ventriculostomy
Verified date | March 2017 |
Source | University Hospital, Toulouse |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Background: Endoscopic third ventriculostomy (ETV) is a standard procedure for the treatment
of obstructive hydrocephalus in children and adults. Perforation of the third ventricle
floor which is part of the hypothalamic-pituitary neuronal network is the key of this
surgical procedure.
Purpose: There are no prospective data available about the endocrine effects after ETV in
children and adults. The principal aim of this prospective study is to evaluate the
variability of hypothalamic-pituitary hormones and clinical effects in children and adults
after ETV in order to plan a multicentric study.
Status | Terminated |
Enrollment | 11 |
Est. completion date | July 2015 |
Est. primary completion date | July 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 6 Months and older |
Eligibility |
Inclusion Criteria: - all patients over 6 months old with obstructive hydrocephalus who are referred for planned endoscopic third ventriculocisternostomy Exclusion Criteria: - MRI contraindication, non obstructive hydrocephalus, life expectancy inferior of 3 months, ETV in emergency, hydrocephalus aetiology interaction with hypothalamic-pituitary hormones, hydrocephalus already treated, basilar artery malformations, to be allergic to tetracosactide (synacthene) and to benserazide (Levodopa). |
Country | Name | City | State |
---|---|---|---|
France | Univesity Hospital Toulouse | Toulouse |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Toulouse |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Variability of hypothalamic-pituitary hormones after endoscopic third ventriculostomy | Complete hypothalamic-pituitary hormonal evaluation | 12 months |
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