Study on Therapeutic Mechanism of Natural Psychotherapy for Neurosis

Obsessive-Compulsive Disorder Clinical Trial

Official title:

Study on Therapeutic Mechanism of Natural Psychotherapy for Neurosis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06443125
• Other study ID #: CASPsy6
• Status: Recruiting
• Phase: N/A
• Start date: August 1, 2023
• Est. completion date: August 1, 2025

Study information

• Verified date: May 2024
• Source: Beijing HuiLongGuan Hospital
• Contact: Zhang Y Xiang, M.D., Ph.D
• Phone: +86-10-62710644
• Email: zhangxy[@]psych.ac.cn
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

explore objective indicators of the efficacy of natural psychotherapy in the treatment of disorders such as obsessive-compulsive disorder

Description:

1. To evaluate the cognitive function, Cognitive control, emotion and other aspects of neurosis patients, and to understand and master the cognitive behavior indicators of this population.

2. Investigate the pathological mechanism of neurotic patients from the aspects of electroencephalic graph/functional magnetic resonance imaging (EEG/fMRI) and biology.

3. To investigate the therapeutic effect of natural psychotherapy on cognitive impairment and related mood, sleep and symptom intervention in neurotic patients. In order to achieve the symptoms of neurosis patients, cognitive impairment and related mood and sleep intervention and promotion, while providing a scientific basis for neurosis rehabilitation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: August 1, 2025
• Est. primary completion date: August 1, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 15 Years to 60 Years

Eligibility

Inclusion Criteria:

• Have a diagnosis of obsessive-compulsive disorder or compulsive behavior

• Duration of symptoms for not less than 12 months

• Age 15-60 years old.

• You can participate in the whole experiment and offline assessment in Beijing

Exclusion Criteria:

• Documented disease of physical diseases including, but not limited to stroke, tumor, Parkinson's disease, Huntington's disease, seizure, epilepsy, history of brain trauma

• Subjects who suffered from alcohol or illegal drug abuse/dependence

Related Conditions & MeSH terms

• Obsessive-Compulsive Disorder

Intervention

Other:
• Natural psychotherapy
Draw ideas from traditional Chinese culture, learn from the practice of Morita therapy in Japan, and create local practice experience. At the same time, a variety of research methods such as cognitive assessment and brain imaging were used to establish the scientific, professional and objective evaluation indexes of the therapy.

Locations

Country	Name	City	State
China	Institute of Psychology, Chinese Academy of Sciences	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Xiang Yang Zhang

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Obsessive-compulsive symptoms	Obsessive-compulsive symptoms were assessed according to the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), The total score ranges from 0 to 40, with higher scores indicating more severe symptoms.	Baseline, 12 weeks
Primary	Cognitive function	Cognitive inhibition was assessed using the emotional color-word Stroop task. The emotional Stroop task is a type of being Widely used cognitive inhibition assessment tools. The longer the reaction time, the worse the cognitive inhibition ability.	Baseline, 12 weeks
Primary	Mood and behavior	Mood changes judged using gait and face recognition	Baseline, 12 weeks
Primary	ERP components associated with cognitive function	To explore the ERP component analysis related to cognitive inhibition and Behavioral inhibition in obsessive-compulsive disorder (OCD) by event related potential (ERP) analysis	Baseline, 12 weeks
Primary	rest fMRI in Obsessive-compulsive patients	The changes of resting-state functional connectivity were analyzed in patients with OCD before and after intervention. Resting-state functional connectivity:FC(Functional connectivity). Resting-state functional brain imaging data were collected using a GE 3.0T magnetic resonance scanner (GE Discovery MR750) at the Brain Imaging Center, Institute of Psychology, Chinese Academy of Sciences.	Baseline, 12 weeks
Primary	Behavioral inhibition	behavioral inhibition was assessed using the emotional stop signal task (SST). The emotional SST task is a type of being Widely used behavioral inhibition assessment tools. Among them, the greater the SSRT, the worse the behavioral inhibition ability.	Baseline, 12 weeks