Using Personalized Assessments in the Treatment of Childhood OCD

Obsessive-Compulsive Disorder Clinical Trial

Official title:

Using Personalized Assessments in the Treatment of Childhood OCD

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06407648
• Other study ID #: IRB00406231
• Status: Recruiting
• Phase: N/A
• Start date: April 3, 2024
• Est. completion date: December 30, 2025

Study information

• Verified date: May 2024
• Source: Johns Hopkins University
• Contact: Alexandra Chang
• Phone: 443-300-8836
• Email: coach[@]jhmi.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The primary purpose of this study is to learn whether personalized assessment of obsessive-compulsive disorder (OCD) symptoms in childhood OCD using mobile health technology are feasible and acceptable for youth and parents. The investigators will also examine whether personalized cognitive-behavioral therapy (CBT) that is informed by personalized OCD assessments yields better clinical outcomes when compared to standard CBT for youth with OCD

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: December 30, 2025
• Est. primary completion date: June 30, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 8 Years to 17 Years

Eligibility

Inclusion Criteria:

1. be 8-17 years of age;

2. meet diagnostic criteria for a primary diagnosis of OCD on a structured clinical interview;

3. have moderate OCD severity as evidenced by a CY-BOCS total score of =16;

4. medication free and/or on a stable dose of medication 8 weeks prior to study participation;

5. be English speaking.

Exclusion Criteria:

1. the presence of psychotic disorder, bipolar disorder, or autism spectrum disorders;

2. significant suicidal ideation that warrants medical intervention;

3. concurrent psychotherapy for OCD;

4. inability to complete scales, or attend visits.

Related Conditions & MeSH terms

• Obsessive-Compulsive Disorder

Intervention

Other:
• Personalized Assessments
Personalized CBT will use individualized OCD symptom networks to guide CBT strategies to target central symptom nodes in contemporaneous networks.
• Standard of Care
The standard CBT condition will use standard-of-care approaches to guide CBT strategies to target OCD symptoms.

Locations

Country	Name	City	State
United States	Johns Hopkins University School of Medicine	Baltimore	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
Johns Hopkins University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Children's Yale-Brown Obsessive-Compulsive Scale Second Edition (CY-BOCS-II) Total Severity Score	A clinician-rated measure of OCD symptom severity in the past week. This 10-item measure is rated on a 0 to 5 scale with a total score ranging from 0 to 50. A higher total score is reflective of greater OCD symptom severity.	Screen, Baseline (Week 0), Week 4, Week 8, and Week 12