Imaging-Guided Low Intensity Focused Ultrasound (LIFU) — LIFU  

Obsessive-Compulsive Disorder Clinical Trial

Official title: Imaging-Guided Low Intensity Focused Ultrasound (LIFU) Neuromodulation of Ventral Striatum in Obsessive-Compulsive Disorder (OCD)

Status Recruiting

Clinical Trial Summary

This research study is to investigate the safety, feasibility, and possible therapeutic benefits of a technology called Low Intensity Focused Ultrasound (LIFU) in patients with obsessive- compulsive disorder (OCD). The device used in this study transmits high frequency sound waves to a particular region of the brain called the Ventral Striatum (VS). LIFU is a non-invasive form of stimulation, which can be used to stimulate deep regions of the brain. In this study, the investigators will administer LIFU to activate the VS area of the brain while also observing this brain stimulation with an MRI machine. Other aims of this study include learning more about the patterns of brain activity associated with OCD and seeing if brain activity changes as symptoms of OCD change over time during the two weeks of LIFU stimulation. Participants in this study will be asked to perform computer administered behavioral tasks -- similar to simple computer games -- to examine whether certain features of OCD (e.g., avoidance of feared triggers) change over the course of LIFU stimulation.

The treatment phase of this research study is expected to last two weeks with three weekly (total of 6) treatment sessions all carried at the MRI brain imaging center at Baylor College of Medicine. There will be at least one additional screening visit before treatment starts and a series of follow up visits over a six-month period.

Clinical Trial Description

The current project will investigate a novel neurostimulation approach, low intensity focused ultrasound (LIFU), which combines non-invasiveness and a sharp spatial focus in deep brain regions. This open-label early feasibility study will be conducted in 20 subjects with OCD across two centers, Baylor College of Medicine (BCM) and Massachusetts General Hospital (MGH). Eligible subjects must have failed ERP and at least two trials of SRIs.

The study will use an MR-compatible Brainsonix (Pulsar 1002) transcranial device containing a single-element, air-backed, spherical section LIFU transducer with a diameter of 61mm and focal depth of either 65mm or 80mm, operating at a fundamental frequency of 650kHz. The selection of either a 65mm or 80mm transducer (as well as 0 or 5 gel pad) will depend upon the individual patient's head size/brain anatomy to optimally target the VS. The transducer is mounted in a plastic head holder and ultrasonic gel pad. LIFU will be administered in the Siemens Prisma 3T MR scanner to enable precise targeting of the ventral striatum (VS).

Each subject will receive 3 LIFUP sessions per week for two weeks (total=6 image-guided treatments). LIFU intensity will be at or below FDA safety limit of 720 mW/cm^2 Ispta, which resulted in an IRB/FDA determination of Non-Significant Risk (NSR) in our study of LIFU targeting the VS in healthy subjects. Outcome measures include safety (e.g., vital signs, adverse event reporting, tolerability, etc.), standardized symptom scales (e.g., change in YBOCS from baseline to assess OCD severity) as well as surrogate measures (e.g., behavioral tasks that assess constructs central to OCD). Subjects will be assessed clinically weekly for 8 weeks and then monthly for total of 6 months. Resting-state fMRI will be performed at baseline and at the end of the two-week study to assess changes in functional connectivity induced by LIFU treatment.

A total of 20 sonications will be administered to one side of the head, with a derated (based on FDA standard of 0.3 dB/cm-MHz) spatial-peak temporal-average intensity (i.e., Ispta) of approximately 720mW/cm2, each lasting 30 s, separated by 30 s pause intervals. Thus, total duration of sonication will be 10 minutes, the same as used in our study of VS LIFU in healthy subjects. Sonication will be administered within a 3T Siemens Prisma scanner. During sonication, the investigators will use the 20-channel head coil as the 32-or 64-channel coil does not allow enough space to fit the transducer.

Once the patient is brought to the MR suite, the investigators will acquire baseline resting-state BOLD MRI without the transducer in the coil. Then, the participant is taken out of the scanner, and the transducer is manually placed and secured to one side of the patient's head, over the temporal bone thinning. Using a lower resolution/faster acquisition T1 MPRAGE in a 3D MPR view, the investigators will navigate to the center of the transducer in one of the windows (sagittal). Then in both the coronal and axial views, the investigators will move the axes so that one is parallel to the face of the transducer, and then the other axis is positioned perpendicularly to it. The investigators will then trace the trajectory of both perpendicular axes to the appropriate focal depth. The investigators will then determine if the investigators are on target or not, estimate how much to adjust if necessary, pull the subject out, adjust as necessary, and repeat the process. Once the investigators are satisfied that the positioning is satisfactory, the investigators will proceed with a pilot stimulation straddled by a pair of baseline and post-stimulation ASL perfusion MRI scans and BOLD fMRI with concurrent LIFU stimulation. Then, the subject will once again be removed from the scanner, the transducer will be removed, and post-stimulation resting-state fMRI, high resolution anatomical scans (for image registration) and diffusion MRI will be collected. The LIFUP installation includes a 10 MHz low-pass filter to limit RF noise interference.

In summary, the entire sequence of 20 sonications, each lasting 30s, separated by 30s pause intervals, will be administered over 20 minutes for a total duration of sonication equal to 10 minutes. A physician will remain in the MR suite during the entire time. The subject will be given a squeeze ball switch for use in emergency, and the investigators will communicate with the subject regularly in between scans. Subject will remain in clinic for at least 30 minutes following the treatment. Vital signs, adverse events and self-report measures of mood and anxiety will be recorded.

Massachusetts General Hospital will obtain local IRB approval for their portion of this study ;

Related Conditions & MeSH terms

• Obsessive-Compulsive Disorder

• NCT number: NCT05467085
• Study type: Interventional
• Source: Baylor College of Medicine
• Contact: Lucas Jumper, BS
• Phone: 713-798-4113
• Email: Jumper@bcm.edu
• Status: Recruiting
• Phase: N/A
• Start date: August 1, 2022
• Completion date: August 1, 2025