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Epidiolex in Obsessive Compulsive Disorder and Related Disorders

Obsessive-Compulsive Disorder Clinical Trial

Official title:
An Open-Label Trial of Epidiolex in the Treatment of Obsessive Compulsive Disorder and Related Disorders: Proof of Concept Study

Clinical Trial Summary

The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs). Subjects will be treated in an open-label fashion with Epidiolex for two weeks.

Clinical Trial Description

The primary objective of the proposed study is to evaluate the safety and efficacy of Epidiolex (cannabidiol) in adults with obsessive compulsive and related disorders (OCRDs). OCRDs include obsessive compulsive disorder (OCD), trichotillomania, skin picking, tourettes disorder, and hoarding disorders. These disorders appear linked in terms of phenomenology and possibly biology. Fifteen subjects with OCRDs will be treated in an open-label fashion with Epidiolex (2.5 mg/kg twice daily for one week followed by 5mg/kg twice daily) for two total weeks of active treatment. The hypothesis to be tested is that Epidiolex will result in reduction in symptoms of OCRDs (improvement in symptoms will be indicated by lower scores on established outcome measures of OCRDs symptoms that have been used in prior studies). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04978428
Study type Interventional
Source University of Chicago
Contact Eve K Chesivoir, BA
Phone 7737029066
Email chesivoir@yoda.bsd.uchicago.edu
Status Recruiting
Phase Phase 2
Start date April 14, 2022
Completion date September 2024
View Details
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