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Understanding How Ketamine Brings About Rapid Improvement in OCD — MKET  

Obsessive-Compulsive Disorder Clinical Trial

Official title:
NMDAR Modulation As a Therapeutic Target and Probe of Neural Dysfunction in OCD

Clinical Trial Summary

The purpose of this study is to understand how ketamine brings about rapid improvement in Obsessive-Compulsive Disorder (OCD) symptoms.

Clinical Trial Description

Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. This study aims to build on our discovery that a potent NMDA receptor antagonist, ketamine, has rapid (in hours) and robust therapeutic effects in OCD. The proposed projects test the acute mechanism of action of ketamine at the level of molecules, circuits, and network synchrony to determine how NMDA receptor antagonism modifies the underlying pathology of OCD to relieve repetitive thoughts and behaviors. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02624596
Study type Interventional
Source Stanford University
Contact
Status Active, not recruiting
Phase Phase 2
Start date June 2016
Completion date June 2025
View Details
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