Overlapping Neural Circuits in Pediatric OCD

Status Completed

Clinical Trial Summary

The purpose of this study is to examine the brain functioning of children and adolescent with OCD before and after treatment with Exposure and Response Prevention (EXRP) therapy.

Clinical Trial Description

The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. The investigators will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using pediatric OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future trans-diagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new trans-diagnostic treatments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02421315
Study type	Interventional
Source	New York State Psychiatric Institute
Contact
Status	Completed
Phase	N/A
Start date	October 2014
Completion date	September 30, 2021

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