Obsessive-compulsive Disorder Clinical Trial
The purpose of this project is to study live recordings from neuronal population of the
human nucleus accumbens during the implantation of deep brain stimulation (DBS) electrodes
for the treatment-resistant obsessive compulsive disorder (OCD). The central aim of this
project is to determine if intra-operative electrophysiological data can confirm that the
electrode is located in the nucleus accumbens. This confirmation could allow the placement
of the DBS electrodes with a higher degree of precision. An additional aim of this project
will be to study the activity of the neuronal population of the nucleus accumbens while a
subject is presented with a task involving an unexpected reward.
The investigators central hypothesis is that unexpected reward will be associated with
increase firing and synchrony in the neuronal population. This will translate into
recordable increase activity in the investigators region of interest and therefore confirm
the proper placement of the electrode.
This study enrolled 2 subjects, with 1 subject completing the protocol showing the
feasibility of the experiment. There were electrophysiological variations with the task
presented but no conclusion could be drawn given the small sample size.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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|---|---|---|---|
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|
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