Obsessive Compulsive Disorder Clinical Trial
Official title:
Quetiapine Augmentation to SRIs for Patients With Obsessive Compulsive Disorder, a Double-blind, Placebo-controlled Study
Quetiapine (Seroquel ®), an atypical antipsychotic registered for use in schizophrenia,
which has a very low propensity of extrapyramidal and endocrine side-effects, has also been
studied as an adjunct in OCD. In an open trial, ten patients with OCD who had not responded
to at least three previous treatments with a SRI at maximum dose and duration were assigned
to receive quetiapine in addition to a SRI for 8 weeks. Given the efficacy of quetiapine in
treatment resistant patients, and given its rapid onset of action (4-6 weeks), it is
postulated that the combination of a low dose atypical antipsychotic and a standard dosage
of an SRI as a treatment for patients with OCD might increase the number of responders as
well as the effect size.
PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation. The SR designation
was changed to XR after consultation with FDA.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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