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NCT00264238 Clinical Trial

Memantine Augmentation in Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder Clinical Trial

Official title:
An Open-Label Trial of Memantine to Augment Response in the Treatment of Obsessive-Compulsive Disorder

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00264238
Other study ID # SUSPO34313
Secondary ID
Status Completed
Phase N/A
First received December 9, 2005
Last updated April 8, 2009
Start date January 2006
Est. completion date June 2008

Study information
Verified date April 2009
Source Stanford University
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

The purpose of this study is to determine whether memantine is safe and effective when used as an augmentation to standard treatment for Obsessive-Compulsive Disorder (OCD).

Description:

The purpose of this study is to determine whether memantine (Namenda), in doses up to 20 mg/day, will be effective in treating the OCD of adult patients who have not responded to their OCD medication. Memantine is not FDA approved for OCD, but is approved for the treatment of Alzheimer's Disease. Memantine appears to work by regulating the activity of glutamate, one of the brain's specialized messenger chemicals, which may play a role in OCD. All patients in the study will receive memantine; no one will receive placebo.

Recruitment information / eligibility
Status Completed
Enrollment 15
Est. completion date June 2008
Est. primary completion date June 2008
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- at least 18 years of age

- suffering from OCD

- Y-BOCS score of 18 or greater

- taking a therapeutic dose of an anti-OCD medication specified in the protocol

Exclusion Criteria:- diagnosed with a mental disorder other than OCD

- taking tiagabine or pregabalin

- having had a previous trial of memantine

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• Memantine

Locations
Country Name City State
United States Stanford University School of Medicine Stanford California

Sponsors (1)
Lead Sponsor Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Y-BOCS score at final study visit
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