A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS)

Status Completed

Clinical Trial Summary

Obesity is an escalating problem in the UK and a proportion of these patients have a condition known as Obesity Hypoventilation Syndrome (OHS). This syndrome is associated with symptoms of breathlessness, reduction in exercise capacity, fatigue and headaches. Previous research has shown that patients with this condition tend to use healthcare services more frequently and are often at risk of other diseases such as diabetes mellitus and high blood pressure. Currently, the mainstay of treatment is noninvasive ventilation (NIV), this is a mask ventilator that patients use overnight to improve oxygen levels and remove carbon dioxide (the waste gas of breathing), however this does not fully treat the underlying problem. The research group has shown that NIV helps improve activity and contributes to weight loss in this group of patients. The aim of this research will be to investigate the effect of an exercise and nutrition programme in addition to NIV on weight loss and activity levels compared to NIV alone.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01483716
Study type	Interventional
Source	Guy's and St Thomas' NHS Foundation Trust
Contact
Status	Completed
Phase	N/A
Start date	November 2011
Completion date	August 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01903135` - Prevalence of Obesity Hypoventilation Syndrome	N/A
Recruiting	`NCT04098094` - Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Withdrawn	`NCT03861468` - Medico-economics and QoL of Obese Patients Followed by Medical Analysis Laboratories (BIOSAOS )	N/A
Completed	`NCT01368614` - AVAPS-AE Efficacy Study	N/A
Terminated	`NCT01964339` - Obesity Hypoventilation Syndrome Prevalence Study
Completed	`NCT04108819` - Ketogenic Diet for Obesity Hypoventilation Syndrome	N/A
Completed	`NCT02934581` - Prevalence Rate, and Clinical Characteristics of Obesity Hypoventilation Syndrome Via Screening Patients Admitted to Medical Intensive Care Units
Terminated	`NCT03353064` - Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure	N/A
Completed	`NCT03085537` - Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
Recruiting	`NCT02980770` - Postoperative Complications in Patients With Obesity Hypoventilation Syndrome	N/A
Completed	`NCT01499485` - Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.	Phase 3
Completed	`NCT03506906` - The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation	N/A
Terminated	`NCT02317042` - Juno Perth Clinical Trial	N/A
Completed	`NCT01405976` - Alternative of Treatment in Obesity Hypoventilation Syndrome	N/A
Withdrawn	`NCT01104610` - Target Volume Mode Controlled Ventilator in Obesity Hypoventilation Syndrome	N/A
Recruiting	`NCT03854058` - Respiratory Muscle Strength in Patients With Obesity Hypoventilation Syndrome (OHS) or With a Precursor of the Disease
Not yet recruiting	`NCT05190458` - Evaluation of High Velocity Nasal Insufflation in Management of Respiratory Failure in Patients With Overlap Syndrome	N/A
Recruiting	`NCT04100616` - A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity
Completed	`NCT02342899` - Cost Effectiveness of Outpatient Set-up of Automated NIV in Obese Patients With Chronic Respiratory Failure	Phase 3
Completed	`NCT01757444` - Non Invasive Ventilation : Efficacy of a New Ventilatory Mode in Patients With OHS	N/A