Clinical Trials Logo

Clinical Trial Summary

Vitamin D (VD) is a pleiotropic hormone, involved in many physiological processes including calcium and phosphorus absorption. The VD metabolism begin to be well-known and involves a hepatic hydroxylation (mediated by enzymes, which belong to the cytochrome P450 family) leading to the production of the 25(OH)D, which corresponds to the circulating form of the VD. After circulation in blood, the 25(OH)D is submitted to a second hydroxylation in the kidney resulting to the generation of 1,25(OH)2D, the active metabolite of VD. Numerous epidemiological studies reported an inverse relationship between obesity and circulation level of 25(OH)D. Several mechanisms could explain the low level of 25(OH)D observed in obese subjects, the more classical evoked being based on sequestration and/or dilution of VD in adipose tissue (AT), the main VD storage site. However, this mechanism has never been demonstrated. In order to confirm this hypothesis, the concentration of VD and its metabolites in adipose tissue need to be quantified.

The objective of this study is to determine the concentration of VD and its metabolites in adipose tissue as well as adipose tissue mass quantification and distribution (visceral or subcutaneous) to highlight putative difference of VD and its metabolites quantities between obese and non-obese patients. A quantification of VD metabolism, inflammation and lipid metabolism gene expression will be realized on biopsies. Correlations between gene expression and quantity of VD in tissue will be carrying out.


Clinical Trial Description

n/a


Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science


Related Conditions & MeSH terms


NCT number NCT03008525
Study type Interventional
Source Assistance Publique Hopitaux De Marseille
Contact Rene VALERO
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date January 2017
Completion date January 2019

See also
  Status Clinical Trial Phase
Completed NCT03650790 - C1q/TNF-related Protein 9 (CTRP 9) Level in Preeclamptic Obese and Non-obese Pregnancies N/A
Completed NCT03638843 - Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy - Part 2 N/A
Completed NCT03239782 - The "Metabolically-obese Normal-weight" Phenotype and Its Reversal by Calorie Restriction N/A
Recruiting NCT04100616 - A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity
Completed NCT03526263 - Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy N/A
Completed NCT03527446 - Acute and Chronic Metabolic Flexibility in Individuals Living With Obesity: The i-FLEX Study N/A
Recruiting NCT04573998 - Study on the Mechanism of lcn2 in Obesity
Recruiting NCT04417582 - Life Style Modification Medical and Surgical Management in Patients With Obesity
Recruiting NCT04924738 - Female Obesity Cohort and Intervention Study Group (MOCART Study Group)
Active, not recruiting NCT04305093 - Data Mining: Precision Analytical Retrospective Data Correlation
Completed NCT04019860 - Time-restricted Eating and High Intensity Interval Training Among Women N/A