Obesity Associated Disorder Clinical Trial
— RespiratoryOfficial title:
Response of Respiratory and Hemodynamic Parameters to Positive End-Expiratory Pressure Titration for Mechanically Ventilated Obese Patients: A Randomized Clinical Trial
Verified date | February 2023 |
Source | Cairo University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, the sixty mechanically ventilated class I obese patients were divided into two equal groups A and B. group A received RTP position + PEEP protocol, while group B underwent RTP position protocol only. The results showed that the group A protocol has positive effects on the improvement of respiratory mechanics by significant increase the arterial oxygen partial pressure (PaO2) in mmHg to fractional inspired oxygen (FiO2), (PaO2/FiO2 ratio), partial pressure of carbon dioxide (PaCO2), and static compliance (Cstat) parameters. Moreover, a significant decrease in hemodynamics of BP& MAP was measured. While the results of the group B protocol demonstrated a non-significant increase in the PaO2/FiO2 ratio, PaCO2, and Cstat. Besides, non-significant decreases in hemodynamics of blood pressure (BP) & mean arterial blood pressure (MAP) were recorded.
Status | Completed |
Enrollment | 60 |
Est. completion date | June 30, 2022 |
Est. primary completion date | June 17, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 50 Years |
Eligibility | Inclusion Criteria: - Subjects included in this study had the following criteria: 1. Mechanically ventilated obese patients in operation room undergoing upper abdominal surgeries (bariatric) and under general anesthesia. 2. Obese patients with BMI (30-34.9). 3. Age 40-50 years old. 4. Both sexes. 5. Non-smoker. 6. No history of disease affecting the heart & lungs. Exclusion Criteria: - Subjects with any of the following were excluded from the study: 1. Severe head injury. 2. Increase intracranial pressure and who are potentially liable to develop pathologically raised intracranial pressure. 3. Acute pulmonary edema. 4. Barotrauma/volutrauma. 5. Un-drained Pneumothorax/Hemothorax. 6. Flail chest. 7. Low blood pressure (systolic less than 80 mmHg). 8. Oxygen saturation is less than 90%. |
Country | Name | City | State |
---|---|---|---|
Egypt | Al Kasr Al Aini Teaching Hospital | Giza |
Lead Sponsor | Collaborator |
---|---|
Heidy F. Ahmed |
Egypt,
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* Note: There are 23 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Respiratory parameters | The primary outcomes included the respiratory parameters partial oxygen pressure, partial carbon dioxide pressure, static compliance fractional oxygen pressure ratio | Immediately after the procedure is done in the operating room appears on the patient's monitor & patient arterial blood gases. | |
Secondary | Hemodynamics parameters | The secondary outcomes included the hemodynamics parameters (SBP in mmHg, DBP in mmHg, and MAP in mmHg). | Immediately after the procedure is done in the operating room appears on the patient's monitor. |
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