The Effects of a Combined Exercise Training Program on Vascular Health and Metabolic Profile in Obese Adolescent Girls.

Obesity, Adolescent Clinical Trial

Official title:

The Effects of a 12- Week Combined Exercise Training Program on Arterial Stiffness, Endothelial Function, Inflammatory Markers and Metabolic Profile in Obese Adolescent Girls: A Pilot Study.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03146026
• Other study ID #: PusanNU-2
• Status: Completed
• Phase: N/A
• Start date: February 8, 2010
• Est. completion date: May 6, 2011

Study information

• Verified date: October 2020
• Source: Pusan National University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to examine the impact of 12 weeks of combined exercise training (CET) on arterial stiffness, endothelial function, inflammatory markers, insulin resistance, and body composition in obese adolescent girls. Thirty obese adolescent girls participated in this study. The girls were randomly divided into CET group (n=15) and control group (n=15). The CET group performed concurrent resistance training followed by aerobic training at 40-70% of the heart rate reserves (HRR) 3 days/week for 12 weeks. Plasma nitric oxide, endothelin-1, C-reactive protein, arterial stiffness, homeostasis model assessment of insulin resistance (HOMA-IR), glucose, insulin, and the adiponectin/leptin ratio were measured before and after the 12-weeks study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: May 6, 2011
• Est. primary completion date: May 2, 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 14 Years to 16 Years

Eligibility

Inclusion Criteria:

• Obese with hyperinsulinemia

• Abdominal obesity

• Sedentary (no regular exercise training or physical activity)

• No weight loss diet during last 6 months.

Exclusion Criteria:

• Hypertension

• Pregnancy

• Chronic disease

Related Conditions & MeSH terms

• Obesity, Adolescent
• Pediatric Obesity

Intervention

Behavioral:
• Combined Exercise Training
The CET program was performed for 60 minutes with 5 minutes of warm-up and cool-down per day, 3 times a week for 12 weeks. Combined exercise consisted of 20 minutes of various resistant band exercises (Upper body: seated rows, biceps curl, shoulder flexion, elbow flexion, chest press; Lower body: hip flexion, hip extension, calf raise, leg press, squat) and 30 minutes of treadmill walking. The warm-up and cool down consisted of static stretching. Intensity of exercise was gradually increased from 40-50% heart rate reserve (HRR) in weeks 1-4, and to 60-70% HRR in weeks 9-12. Each training session was fully supervised by the researchers. Every subject wore a heart rate monitor during the whole training session so as to maintain the correct training intensity.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Pusan National University	University of Nebraska

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Arterial stiffness	Arterial stiffness was measured as measurement of baPWV (m/s).	12 weeks
Primary	Endothelin-1	Levels of Endothelin-1 in blood were measured by Endothelin-1 enzyme immunoassay kit.	12 weeks
Primary	Insulin resistance	Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR).	12 weeks
Primary	Plasma leptin	Plasma leptin was determined by ELISA kit	12 weeks
Primary	Plasma adiponectin	Plasma adiponectin was measured using ELISA kit	12 weeks
Primary	Body weight	Body weight was measured to nearest 0.1 kg.	12 weeks
Primary	Height	Height was measured to nearest 1 cm.	12 weeks
Primary	Waist circumference	Waist circumference was measured at midpoint between the lower rib and the iliac crest at the end of a normal expiration using a tape measure	12 weeks
Primary	Body fat	Percent body fat (%) was determined using a bioelectrical impedance-meter.	12 weeks
Primary	Maximal heart rate	Maximal heart rate was obtained at the end of a graded treadmill exercise test performed until volitional exhaustion.	12 weeks
Primary	Nitric oxide	Nitric oxide generation was measured by Griess assay kit.	12 weeks