Effects of Aerobic and Resistance Training on Abdominal Fat Loss

Obesity, Abdominal Clinical Trial

Official title:

Effects of Aerobic and Resistance Training on Abdominal Fat Loss

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03700827
• Other study ID #: 16-1208-4C-2
• Status: Terminated
• Phase: N/A
• Start date: October 1, 2017
• Est. completion date: May 1, 2020

Study information

• Verified date: March 2021
• Source: Southern Illinois University Edwardsville
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 18
• Est. completion date: May 1, 2020
• Est. primary completion date: April 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• 30 - 39.9 kg/m2 BMI
• White/Caucasian
• Female
• Sedentary

Exclusion Criteria:

• Known cardiovascular, pulmonary, metabolic disease
• Pregnant females
• Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos)
• Diabetic
• Hypertension
• Cigarette smoking
• MRI related contraindications (metal, no removable devices, etc.)

Related Conditions & MeSH terms

• Obesity, Abdominal

Intervention

Other:
• Resistance Training
High-intensity Resistance Training Group
• Aerobic Training
Aerobic Interval Training Group

Locations

Country	Name	City	State
United States	Southern Illinois University of Edwardsville	Edwardsville	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
Southern Illinois University Edwardsville	Washington University School of Medicine

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in Visceral Abdominal Tissue (VAT)	Changes in VAT will be measured using Magnetic Resonance Imaging	2 assessment periods: at baseline and week 4
Secondary	Changes in Subcutaneous Abdominal Tissue (SAT)	Changes in SAT will be measured using Magnetic Resonance Imaging	2 assessment periods: at baseline and week 4
Secondary	Changes in Muscular Strength	Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press	2 assessment periods: at baseline and week 4
Secondary	Changes in Cardiorespiratory Function	Changes in cardiorespiratory will measured on a treadmill with a metabolic cart	2 assessment periods: at baseline and week 4
Secondary	Changes in fat mass (kg)	Changes in fat mass will be measured using dual-energy x-ray absorptiometry	2 assessment periods: at baseline and week 4
Secondary	Changes in relative body fat (%BF)	Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry	2 assessment periods: at baseline and week 4
Secondary	Changes in relative lean body mass (kg)	Changes in lean body mass will be measured using dual-energy x-ray absorptiometry	2 assessment periods: at baseline and week 4
Secondary	Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL)	Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis	2 assessment periods: at baseline and week 4
Secondary	Changes in concentration of Troponin	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Secondary	Changes in concentration of Fibrinogen	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Secondary	Changes in concentration of C-reactive protein (CRP)	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Secondary	Changes in concentration of IL-6	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Secondary	Changes in concentration of IL-10	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Secondary	Changes in concentration of TNF-alpha	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4