Nutrition Clinical Trial
Official title:
The Dose-response of Vitamin C-enriched Collagen on Markers of Collagen Synthesis in Middle-Aged Men and Women Following Resistance Exercise
Verified date | January 2024 |
Source | Liverpool John Moores University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study aimed to investigate the effect of different doses of hydrolyzed collagen (HC) with resistance exercise (RE) on whole body collagen synthesis in middle-aged males and females.
Status | Completed |
Enrollment | 10 |
Est. completion date | September 30, 2023 |
Est. primary completion date | September 30, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 65 Years |
Eligibility | Inclusion Criteria: - At least 12 months experienced in resistance exercise (including weekly lower body exercise) - Free from musculoskeletal injury Exclusion Criteria: - Having a history of patellar tendon pathology - Vegan - Consumed nutritional supplements or medication purported to have beneficial effects on muscle-tendon properties (e.g. antioxidants, protein, etc.) - Had a sustained a lower limb injury in the previous six months - Smoker/vaper - Having reached menopause (only for middle-aged female participants) |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Dr Rob Erskine | Liverpool |
Lead Sponsor | Collaborator |
---|---|
Rob Erskine | University of East Anglia |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in a marker of collagen synthesis | Serum procollagen type ? N-terminal propeptide (P?NP) concentrations were measured following 0 grams, 15 grams or 30 grams hydrolyzed collagen (HC) intake with resistance exercise (RE) during all interventions. | At rest immediately prior to HC ingestion, 0.5-hour post RE, 1-hour post RE, 2-hour post RE, 4-hour post RE and 6-hour post RE | |
Primary | Change in a marker of collagen breakdown | Plasma ß-isomerized C-terminal telopeptide of type I collagen (ß-CTX) concentrations were measured following 0 grams, 15 grams or 30 grams hydrolyzed collagen (HC) intake with resistance exercise (RE) during all interventions. | At rest, immediately prior to HC ingestion, 0.5-hour post RE, 2-hour post RE and 6-hour post RE | |
Secondary | Estrogen concentrations in women in each trial | Concentrations of estrogen (17ß-estradiol) was measured in each intervention. | At rest immediately prior to HC ingestion | |
Secondary | Changes in amino acids concentrations in blood | Concentration of serum amino acids that constitute collagen was measured following 0 grams, 15 grams or 30 grams hydrolyzed collagen (HC) intake with resistance exercise (RE) during all interventions. | At rest immediately prior to HC ingestion, 0.5-hour post HC ingestion, 1-hour post HC ingestion, 0.5-hour post RE, 1-hour post RE, 2-hour post RE, 4-hour post RE and 6-hour post RE |
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