Clinical Trials Logo

Clinical Trial Summary

The aim of the study will be to evaluate the impact of consumption of meat and dairy products from extensive or intensive farming on apparently healthy individuals aged between 45 and 65 years, a stage of life associated with reduced metabolic flexibility and changes in lipid metabolism. The study will analyze: 1. The transcription factor PPAR-α determined by the gene expression of PPAR-α in white blood cells, variations in circulating fatty acid metabolism, and the endocannabinoid system determined by circulating analysis of N-acylethanolamine (NAE), and 2-monoacylglycerols (2-MG); 2. Metabolic flexibility, determined by indirect calorimetry in fasting condition during an incremental exercise; 3. Body composition, determined by bioimpedance analysis, waist circumference, and waist-to-hip ratio.


Clinical Trial Description

The study will be a double-blind crossover intervention clinical trial conducted on the aforementioned individuals, who will consume "kent'erbas" cheese products, from extensive and intensive farming. The study will include 105 individuals aged between 45 and 65 years, apparently in good health, recruited from the UTIC cardiology unit of A.O.U.CA Cagliari (Italy). All participants will be provided with a detailed explanation of the study procedures and its purpose, and their participation will be contingent upon signing an informed consent form. Throughout the study, subjects will maintain their regular lifestyle and unrestricted food intake. At the outset of the study, relevant information necessary for an appropriate approach to each participant will be collected, including a comprehensive medical history, measurement of anthropometric parameters, and blood sampling for a thorough hematological, inflammatory, and lipid-metabolomic analysis. In the pecorino study, subjects will consume 350g/week of "kent'erbas" pecorino from extensive farming or 350g/week of "industrial" pecorino from intensive farming for 4 weeks in total. At the end of this period, a blood sample will be taken. Subsequently, there will be a 8 weeks washout period during which participants will follow their usual diet without consuming either type of pecorino. At the end of the washout period, an additional blood sample will be taken. Following this, the participants who had consumed "kent'erbas" pecorino will switch to "industrial" pecorino for 4 weeks, and vice versa. At the end of this second period, a final blood sample will be collected. The quantities of pecorino cheese chosen for intake are representative of the average consumption in Italy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06012227
Study type Interventional
Source University of Cagliari
Contact Sebastiano Banni
Phone 070-6754128
Email banni@unica.it
Status Recruiting
Phase N/A
Start date January 20, 2022
Completion date December 20, 2026

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05934318 - L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) N/A
Recruiting NCT05867433 - Strong Teens for Healthy Schools Change Club: A Civic Engagement Approach to Improving Physical Activity and Healthy Eating Environments N/A
Completed NCT02376530 - Price Changes and Nutrient Profiling Among Adult Grocery Shoppers N/A
Completed NCT00957814 - Nutritional Orientations and Adherence, Nutritional Status, Clinical and Life Quality Parameters of Heart Failure (HF) Patients N/A
Completed NCT01040975 - Teen CHAT: Improving Physician Communication With Adolescents About Healthy Weight N/A
Completed NCT00808756 - Study on Fermentable Carbohydrates in Healthy Infants N/A
Completed NCT03290118 - The Efficacy of Front-of-package Labelling Schemes: an Experimental Study N/A
Completed NCT03575884 - Fit 5 Kids Screen Time Reduction Curriculum for Latino Preschoolers N/A
Completed NCT03963778 - Organisational Culture and Nutritional Care
Completed NCT05633251 - Using Reinforcement Schedules to Increase Fruit&Vegetable Intake, Reduce Waste, and Increase School Lunch Participation N/A
Recruiting NCT05977959 - Optimizing the Impact of the Healthy School Recognized Campus Program on Youth's CVD Risk Factors N/A
Recruiting NCT05138276 - Effect of Autologous Cord Blood Mononuclear Cells for Digestive System in Preterm Neonates Early Phase 1
Completed NCT03906851 - Active and Healthy Kids in Telemark - a School Based Health Promoting Intervention N/A
Not yet recruiting NCT02950779 - Assessment of Handgrip Strength in Adults With Inflammatory Bowel Disease N/A
Completed NCT02486588 - Increasing Engagement With a Healthy Food Benefit N/A
Withdrawn NCT01184027 - Impact of Nutrition and Swallowing Function of Head and Neck Cancer Patients During the Course of Treatment N/A
Completed NCT01178398 - Understanding Fish Consumption Habits During Pregnancy N/A
Completed NCT01249508 - Nutrition Labeling Program to Promote Healthy Dietary Patterns N/A
Terminated NCT00577499 - Effect of Lubiprostone on Nutritional Status and Pulmonary Function in Adults With Cystic Fibrosis N/A
Completed NCT00109551 - Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal Phase 3