Nutrition Intervention Clinical Trial
Official title:
The Effect of Monosodium L-glutamate (MSG) on Satiety and Energy Intake in Overweight and Obese Women
Verified date | May 2015 |
Source | Ajinomoto Co., Inc. |
Contact | n/a |
Is FDA regulated | No |
Health authority | United Kingdom: Research Ethics Committee |
Study type | Interventional |
The objective of this study is to compare energy intake following consumption 0.5% MSG versus a control with no added MSG and matched for sodium in healthy non-smoking premenopausal female adults.
Status | Completed |
Enrollment | 75 |
Est. completion date | October 2012 |
Est. primary completion date | September 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 19 Years to 60 Years |
Eligibility |
Inclusion Criteria: - Healthy Premenopausal Female, 19 to 60 yrs old - Non-smoker - Non-heavy Drinker - BMI between 25 and 39.9 inclusive at the screening visit (with average BMI 30) - no reported current or previous metabolic diseases or chronic gastrointestinal disorders - no medically prescribed diet, no slimming diet, used to eating 3 meals a day and snacking - No blood donation during the study - Reported intense sporting activities = 10h/w - Reported alcohol consumption =14 units/w - Informed consent signed - Recruitment form filled out Exclusion Criteria: - Smoker - Vegetarian - Disliking the meals provided on the test day, have allergy or intolerance to test products or study meals - Use of medication which interferes with study measurements (as judged by the study physician). - Possible eating disorder (measured by SCOFF questionnaire score >1) - Current depression measured by BDI <10 - Pregnant during the study period or in the six months prior to pre-study investigation - Reported lactating 6 weeks before pre-study investigation and during the study - Reported weight loss or gain = 10 % of bodyweight during a period of six months before pre-study examination. - Eating disorder (measured by SCOFF questionnaire, =2 "yes" responses) - Reported participation in another biomedical trial 1 month before the start of the study |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
United Kingdom | Leatherhead Food Research | Leatherhead | Surrey |
Lead Sponsor | Collaborator |
---|---|
Ajinomoto Co., Inc. |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | The difference in subjective feelings of appetite using visual analogue scales (VAS), compared with a negative control | 8 hours 30 min Postprandial Study | No | |
Other | Taste meal evaluation, including soup liking | 8 hours 30 min Postprandial Study | No | |
Primary | The difference in total energy intake (lunch and snack) compared with a control, as determined by food amount that subject consumed using a food scale (weigh foods before and after). | food will be measured before and after using a food scale (weight out and in) | 8 hours 30 min Postprandial Study | No |
Secondary | The difference in energy intake only at lunch compared with a control, as determined by food amount that subject consumed using a food scale (weigh foods before and after). | food will be measured before and after using a food scale (weight out and in) | 8 hours 30 min Postprandial Study | No |
Secondary | The difference in energy intake of snack only compared with a control | food will be measured before and after using a food scale | 8 hours 30 min Postprandial Study | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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