NSCLC Clinical Trial - Almonertinib Plus Metronomic Oral Vinorelbine

Status Not yet recruiting

Clinical Trial Summary

To evaluate the efficacy of continuing osimertinib in conjunction with metronomic oral vinorelbine after limited progression on osimertinib, to provide clinical experience on the treatment strategy for these patients.

Clinical Trial Description

This study is a clinical observation study. The patients who comfirm the criteria will be treated with Almonertinib plus metronomic oral vinorelbine. The patients will be followed up until the tumor progressed, and the efficacy (PFS, ORR, DCR) of tumor therapy were evaluated. Drug administration regimen: Ametinib 110mg once a day; Oral Vinorelbine 40mg three times a week for three weeks and Q28d for one course. ;

Study Design

Related Conditions & MeSH terms

EGFR
NSCLC

Clinical Trial Details

NCT number	NCT05663177
Study type	Observational [Patient Registry]
Source	Fujian Cancer Hospital
Contact
Status	Not yet recruiting
Phase
Start date	December 20, 2022
Completion date	June 1, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05821933` - RC108 Combine With Furmonertinib With/Without Toripalimab in Patients With EGFR-mutated NSCLC	Phase 1/Phase 2
Active, not recruiting	`NCT03269162` - Postoperative NSCLC Treated With Integrated Medicine Base on Circulating Tumor Cell Detection	Phase 3
Recruiting	`NCT05002270` - JAB-21822 Activity in Adult Patients With Advanced Solid Tumors Harboring KRAS G12C Mutation	Phase 1/Phase 2
Recruiting	`NCT06315686` - The Dynamic Monitoring of Cerebrospinal Fluid ctDNA	Phase 2
Active, not recruiting	`NCT05059522` - Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing	Phase 3
Recruiting	`NCT05466149` - Efficacy and Safety of Furmonertinib in Patients With Locally Advanced or Metastatic NSCLC With EGFR Exon 20 Insertion	Phase 2
Recruiting	`NCT03175224` - APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors	Phase 2
Completed	`NCT03609918` - Comprehensive Analysis of Gene Mutation Profile in Chinese NSCLC Patients by Next-generation Sequencing
Recruiting	`NCT06043817` - First-In-Human Study of STX-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations	Phase 1/Phase 2
Completed	`NCT03652077` - A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies	Phase 1
Recruiting	`NCT05078931` - A Study to Evaluate Pembrolizumab Plus Lenvatinib in PD-L1 Positive TKI Resistant NSCLC Patients	Phase 2
Not yet recruiting	`NCT05547737` - Multicenter, Prospective, Real World Study of Camrelizumab in Cross-line Treatment of Non-small Cell Lung Cancer
Not yet recruiting	`NCT05909137` - Omitting Clinical Target Volume in Radical Treatment of Unresectable Stage III Non-small Cell Lung Cancer
Withdrawn	`NCT05959473` - EGFR_IUO 3.20 Clinical Study Protocol	N/A
Not yet recruiting	`NCT05005468` - A Phase II Trial of Camrelizumab Combined With Famitinib for Adjuvant Treatment of Stage II-IIIA NSCLC.	Phase 2
Recruiting	`NCT01690390` - Dose Escalation of Icotinib in Advanced Non-small Cell Lung Carcinoma (NSCLC) Patients Evaluated as Stable Disease	Phase 2
Completed	`NCT01852578` - Cabazitaxel in Relapsed and Metastatic NSCLC	Phase 2
Active, not recruiting	`NCT01460472` - Immunotherapy With Racotumomab in Advanced Lung Cancer	Phase 3
Completed	`NCT00866970` - Safety, Efficacy and Pharmacokinetics of ALD518 in Patients With Non-Small Cell Lung Cancer-related Fatigue and Cachexia	Phase 2
Completed	`NCT00702975` - Study of Combination Therapy of Carboplatin -Gemcitabine Plus Bevacizumab Beyond Progression in Patients With Locally Advanced and/or Metastatic Non-small Cell Lung Cancer (NSCLC) Who Have Not Received Prior Systemic Therapy	Phase 2