NSCLC Clinical Trial
Official title:
Cognitive Sequelae of Prophylactic Cranial Irradiation in Non-small Cell Lung Cancer Patients
Stage III non-small cell lung cancer (NSCLC) patients constitute a significant proportion of
the lung cancer population. The prognosis of these patients has improved over the years due
the introduction of combined modality treatment, including high-dose chemo-radiotherapy. The
brain, however, remains one of the major sites of failure. Patients with brain metastasis
suffer from a variety of neurological, cognitive and emotional difficulties that are known
to adversely affect the health-related quality of life. Prophylactic Cranial Irradiation
(PCI) can prevent or delay the development of brain metastasis, and as such can improve
neurological disease-free survival and consequently health-related quality of life. But
survival is short, and toxicities are real, as PCI in itself can also induce adverse
effects. The cognitive adverse effects of PCI are not sufficiently illuminated and
documented, due to the lack of formal and systematic evaluation in patient populations
expected to have short survival. Also, recent attempts to reduce cognitive side effects of
PCI by the application of hippocampal-avoidance PCI in order to prevent memory deficits have
not been fully evaluated yet.
Before PCI can be offered routinely to stage III NSCLC patients in daily practice, the costs
and benefits of this therapy should be investigated properly, to allow for well-informed
treatment choices.
n/a
Observational Model: Case-Crossover, Time Perspective: Prospective
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