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Pemetrexed and Carboplatin With or Without Anlotinib Hydrochloride for Osimertinib-resistant Non-squamous NSCLC — PCA  

NSCLC Stage IV Clinical Trial

Official title:
A Multicenter, Randomized, Phase II Study of Pemetrexed and Carboplatin With or Without Anlotinib Hydrochloride for Advanced or Locally-advanced Osimertinib-resistant Non-squamous Non-small Cell Lung Cancer (ALTER-L031)

Clinical Trial Summary

Evaluate the efficacy and safety of Anlotinib Hydrochloride in combination with Pemetrexed and Carboplatin versus Pemetrexed and Carboplatin for advanced or locally-advanced Osimertinib-resistant non-squamous non-small cell lung cancer.

Clinical Trial Description

Anlotinib Hydrochloride in combination with Pemetrexed and Carboplatin use 4 cycles,then continue pem and anlotinib until PD

Pemetrexed and Carboplatin use 4 cycles,then continue pem until PD

TO see the different of PFS and OS and safety between the two group ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04136535
Study type Interventional
Source Fudan University
Contact chang J hua, PD
Phone 18017312689
Email changjianhua@163.com
Status Not yet recruiting
Phase Phase 2
Start date October 18, 2019
Completion date December 31, 2021
View Details
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