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NSCLC, Stage IIIA clinical trials

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NCT ID: NCT05157776 Recruiting - NSCLC, Stage IIIA Clinical Trials

A Phase III Trial of Neoadjuvant Sintilimab and Chemotherapy for NSCLC Harboring No Driver Mutations

Start date: October 28, 2021
Phase: Phase 3
Study type: Interventional

This is a randomized, open-label study designed to evaluate the safety and efficacy of neoadjuvant PD-1 antibody plus chemotherapy followed by surgery in resectable stage IIIA non-small cell lung cancer. The primary endpoint: pCR rate The second endpoint: MPR, DFS, MRD

NCT ID: NCT04865250 Recruiting - NSCLC Stage IIIB Clinical Trials

Predicting Response to Neoadjuvant ATEZOLIZUMAB Plus Carboplatin/Nab Paclitaxel in Resectable Non-squamous NSCLC

iReP
Start date: January 7, 2021
Phase: Phase 2
Study type: Interventional

Exploratory study evaluating the potential of immune signature profiling for predicting response in patients with resectable Stage II, IIIA and select IIIB (T3N2 only) non-squamous Non-Small Cell Lung Cancer (NSCLC) to neoadjuvant ATEZOLIZUMAB plus Carboplatin/nab Paclitaxel Atezolizumab is given as intravenous infusion at a fixed dose of 1200 mg, day 1 of each 21-day cycle (every 3 weeks) for 3 cycles during the neoadjuvant treatment phase, Carboplatin at an initial dose of AUC (area under curve) 5 mg/mL/min, intravenously day 1 of each 21-day cycle for 3 cycles during the neoadjuvant treatment Phase, and Nab-Paclitaxel (Abraxane) at 100 mg/m2, intravenously day 1, 8 and 15 of each 21-day cycle for 3 cycles during the neoadjuvant treatment phase. Surgery after the 3rd cycle Atezolizumab / Carboplatin / Nab-Paclitaxel is standard procedure.

NCT ID: NCT04205552 Recruiting - NSCLC, Stage I Clinical Trials

Neoadjuvant Nivolumab Combination Treatment in Resectable Non-small Cell Lung Cancer Patients

NEOpredict
Start date: March 4, 2020
Phase: Phase 2
Study type: Interventional

The primary objective of this study is to determine the feasibility of four weeks of preoperative immunotherapy with Nivolumab, and Nivolumab plus Relatlimab in patients with early stage or locally advanced non-small cell lung cancer eligible for curative resection.

NCT ID: NCT03736993 Completed - NSCLC, Stage IIIA Clinical Trials

Metabolomics Predict Therapy Response

PROLUNG
Start date: May 28, 2018
Phase: N/A
Study type: Interventional

Complete resection is the mainstay of treatment for stage I-IIIA resectable non-small cell lung cancer (NSCLC). However rates of recurrence of disease are high, with five-year survival rates ranging between 73% (stage IA) and 24% (stage IIIA). Therefore, a prognostic biological marker that stratifies between NSCLC patients whom surgery cures versus patients in whom surgery would be futile due to early disease relapse after surgery is eagerly awaited. The primary objective of this prospective study is to establish a prognostic marker of early disease progression after complete surgical resection in patients with stages I to IIIA NSCLC. For this purpose the investigator will compare the metabolic profile with disease progression or death within one year after complete surgical resection to the patients with a progression free survival. Furthermore the investigator will evaluate the changes in the metabolic profile after surgery and if changes in this metabolic profile over time can predict disease recurrence before it becomes clinically apparent.

NCT ID: NCT03628144 Withdrawn - Clinical trials for Non-small Cell Lung Cancer

Immunonutrition to Reduce Toxicities in Non-Small Cell Lung Cancer

Start date: July 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess whether either or both nutrition supplements (Impact® Advanced Recovery or Boost® High Protein) ingested prior to and during concurrent chemoradiotherapy decreases toxic side effects of treatment in Stage IIIA-B non-small cell lung cancer.

NCT ID: NCT01470716 Active, not recruiting - NSCLC, Stage IIIA Clinical Trials

Neoadjuvant Erlotinib for Operable Stage II or IIIA NSCLC With EGFR Mutations

Start date: January 2012
Phase: Phase 2
Study type: Interventional

This study examines preoperative Erlotinib in patients with operable stage II and IIIA Non-small-cell lung cancer (NSCLC) harboring EGFR mutations.