NPC Patients Clinical Trial
Official title:
The Children and Adolescents Nasopharyngeal Carcinoma Survivor Study
The Children and Adolescents Nasopharyngeal Carcinoma Survivor Study will investigate the long-term effects of nasopharyngeal carcinoma (NPC) and its associated therapies. A prospective and retrospective cohort study will be conducted through a multi-institutional collaboration. This project will study children and adolescents exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
The study will focus on the following objectives:
- Characterize survivors' health with respect to disease- and treatment-related factors.
- Investigate the consequences of various intensities of exposure to chemotherapy and/or
radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc…).
- Compare the mortality experience of survivors with the general population.
- Characterize the health-related behaviors, patterns of medical care, and medical
follow-up needs of survivors.
- Describe patterns of familial aggregation of cancer, including known (and variations of)
cancer family syndromes.
- Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate
with health outcomes and use for future research.
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