Clinical Trials Logo
  1. Home
  2. Normal Volunteers
  3. NCT02113943

Double Blind Randomized, Monocentric, Cross-over, Placebo-controlled Study to Evaluate the Effect of Citalopram on Motivation — MBBCitalopram  

Normal Volunteers Clinical Trial

Official title:
Etude Comparative Monocentrique, randomisée, en Cross-over, en Double Aveugle, Contre Placebo, de l'Action du Citalopram Sur Les paramètres Cognitifs de la Motivation

Clinical Trial Summary

The aim of the current study is to examine the role of serotonin on the cognitive parameters of motivation. They are embedded in a conceptual framework of motivation that merges decision-making and reinforcement learning theories. Every action is conceived as path from one state to another. The different states are associated to different values (positive for rewards and negative for punishments), and the different actions to different costs (risk, effort and delay). The tasks are designed such that the sensitivity to the state and action parameters can be inferred by fitting computational models.The primary objective is to characterize the effect of Citalopram 30mg on reward sensitivity, assessed in an incentive force task, in which participants are asked to squeeze a hand grip to win monetary rewards. Secondary objectives are to characterize the effect of Citalopram 30mg on other cognitive parameters of motivation (assessed with a motivational battery that includes rating, choice and learning tasks).

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02113943
Study type Interventional
Source Institut National de la Santé Et de la Recherche Médicale, France
Contact
Status Completed
Phase Phase 2
Start date April 2014
Completion date June 2014
View Details
See also
  Status Clinical Trial Phase
Completed NCT02922933 - A Study to Examine the Effect of Omeprazole, Famotidine, and an Acidic Beverage on the Pharmacokinetics of Entinostat in Healthy Adult Subjects Phase 1
Completed NCT02922946 - Study to Determine the Effect of the Timing of a Meal on the Pharmacokinetics of Entinostat Phase 1
Completed NCT01250197 - Formulation Comparison in Normal Volunteers Phase 1
Completed NCT02051517 - Vitreous Chemistry Analysis N/A
Completed NCT01185418 - Evaluation of Negative Symptoms and Cognitive Function After Administration of Antipsychotics in Healthy Volunteer N/A
Recruiting NCT00182858 - Tissue Procurement for Biomedical Research
Completed NCT02828813 - Neural Mechanisms of Motor and Cognitive Networks
Completed NCT02146391 - Study to Evaluate the Effect of Food Upon the Pharmacokinetics of Androxal Phase 1
Terminated NCT00465842 - Protein Biomarker in Hepatocellular Carcinoma
Recruiting NCT02471352 - Studies of Dermatologic Diseases Biospecimen Acquisition Protocol
Terminated NCT01752231 - Optimization of Novel DCE-MRI Imaging Sequences for Cancer Therapy Monitoring N/A
Completed NCT02517307 - Fatty Acid Oxidation Defects and Insulin Sensitivity N/A
Completed NCT01366352 - Pharmacokinetics and Bioavailability Comparison of Two Different Formulations of MNTX Tablets Phase 1
Not yet recruiting NCT01487486 - Proteomics & Glyco-Proteomic Analysis of Follicular Fluid N/A
Completed NCT03993587 - The Effect of Head and Shoulder Positioning on the Cross-sectional Area of the Subclavian Vein in Obese Adults
Completed NCT02860351 - The Effect of Head Positioning on the Cross-sectional Area of the Subclavian Vein. N/A