Effects of Consuming Artificial Sweeteners and Sugar on Cerebral and Physiological Responses

Normal Subjects Clinical Trial

— SUGART  

Official title:

Acute Effects of Artificial Sweeteners and Sugar on the Brain Dynamics to Food Image Viewing. An Exploratory, Monocentric, Randomized Controlled Trial in Healthy Young Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02853773
• Other study ID #: 353/15
• Status: Completed
• Phase: N/A
• First received: February 8, 2016
• Last updated: October 24, 2017
• Start date: February 2016
• Est. completion date: September 29, 2017

Study information

• Verified date: July 2016
• Source: University of Lausanne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims at investigating the acute influence of artificially sweetened beverages consumption (as compared with sugar-sweetened beverages and water consumption) on brain responses to the viewing of food images, on physiological responses (gut-derived hormones and lipid metabolites) and on the food intake behavior.

Description:

This study is made on a randomized controlled crossover design including three conditions (water, sugar, artificial sweeteners). Measurements will be performed in fasting and fed conditions. The test-meal will comprise either an artificially or sugar-sweetened beverage or water (control). The spatio-temporal brain dynamics to the viewing of food pictures will be assessed by means of electroencephalography (EEG) recordings and electrical neuroimaging analyses. Venous blood and urine will be collected. Blood pressure, cardiac frequency and bio-impedance measurements will be performed. Food intake behavior will be assessed by means of questionnaires and a free-choice buffet. Each tested condition (water, sugar, artificial sweeteners) will be preceded by a run-in period during which the participants' diet will be controlled (2-day isoenergetic diet).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: September 29, 2017
• Est. primary completion date: September 29, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy

• Caucasian

• Right-handed

• Weak to normal physical activity (< 3hours per week)

• Normal-weight (19<BMI<25 kg/m2)

• Regular consumption of sugar-sweetened beverages (>33cl per week)

Exclusion Criteria:

• Consumption of artificially sweetened beverages exceeding 33cl per week

• Diabetes

• Cardiovascular, kidney, hepatic and/or psychological disorders

• Blood pressure at rest > 140/90mmHg

• Body weight < 50kg

• Hemoglobin < 13.5g/dl

• Ferritin < 50microg/l

• Drug consumption

• Alcohol consumption (>10g/day)

• Smoking

• Any particular diet (e.g. vegetarianism), food allergy and/or intolerance

• Body weight gain or loss of >3kg during the last 3 months

Related Conditions & MeSH terms

• Normal Subjects

Intervention

Other:
• ingestion of a test meal with sweetener
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with artificially sweetened drinks
• ingestion of a test meal with sweetener
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with sugary drinks drinks
• ingestion of a test meal with water
participants will ingest a test meal containing 55% carbohydrate, 30% fat and 15% protein with waters

Locations

Country	Name	City	State
Switzerland	Department of Physiology	Lausanne	Vaud

Sponsors (2)

Lead Sponsor	Collaborator
University of Lausanne	University of Lausanne Hospitals

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Spatio-temporal brain dynamics	Spatio-temporal brain dynamics to the viewing of food will be assessed by means of electroencephalography recordings.	differences observed between 60 min before and 60 min after ingestion of a test meal
Secondary	Changes in concentration of blood insulin	Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal	-120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
Secondary	Changes in concentration of blood triglyceride	Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal	-120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
Secondary	Changes in concentration of blood Fibroblast Growth Factor (FGF)-21	Blood substrate concentration will be measured in fasting conditions and after ingestion of a test meal	-120 min before ingestion of a test meal, and 30, 60, 90, 150, and 210 min after ingestion of a test meal
Secondary	spontaneous food intake	Food intake behavior will be assessed by monitoring spontaneous food intake when offered a free-choice buffet.	240 min after ingestion of a test meal