Clinical Trials Logo
  1. Home
  2. Normal Pressure Hydrocephalus
  3. NCT00600795

Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

Normal Pressure Hydrocephalus Clinical Trial

Official title:
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

Clinical Trial Summary

Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus

Clinical Trial Description

The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12

The specific aims of this research proposal are to:

1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement.

2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00600795
Study type Observational
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase N/A
Start date January 2008
Completion date June 2011
View Details
See also
  Status Clinical Trial Phase
Terminated NCT00149721 - Anterior Pituitary Function in Patients With Hydrocephalus N/A
Completed NCT00196196 - A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System. Phase 3
Not yet recruiting NCT05562596 - Normal Pressure Hydrocephalus Biomarkers Investigation
Unknown status NCT00874198 - European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus N/A
Completed NCT00233701 - Normal Pressure Hydrocephalus (NPH) Registry Phase 4
Withdrawn NCT00793416 - ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Phase 4
Recruiting NCT05910944 - European Study of Prodromal iNPH
Active, not recruiting NCT01909960 - Flow MRI in Normal Pressure Hydrocephalus N/A
Completed NCT02016352 - Cerebrospinal Fluid Proteome in Hydrocephalus N/A
Terminated NCT01092546 - Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus Phase 3
Terminated NCT00613886 - Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus N/A
Completed NCT01815775 - Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery Phase 0
Recruiting NCT03877107 - Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH N/A
Enrolling by invitation NCT03269201 - Brain Network Activation in Patients With Movement Disorders
Recruiting NCT03245138 - Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus N/A
Terminated NCT00727142 - Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH) N/A
Recruiting NCT04471740 - Normal Pressure Hydrocephalus and Sleep Apnea N/A
Completed NCT01798641 - A Randomized Cross-over Study for Normal Pressure Hydrocephalus N/A
Recruiting NCT01618500 - Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus N/A
Terminated NCT03521518 - CPT-3 in Normal Pressure Hydrocephalus