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Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

Normal Pressure Hydrocephalus Clinical Trial

Official title:
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

Clinical Trial Summary

Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus

Clinical Trial Description

The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12

The specific aims of this research proposal are to:

1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement.

2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00600795
Study type Observational
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase N/A
Start date January 2008
Completion date June 2011
View Details
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