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Normal Pressure Hydrocephalus clinical trials

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NCT ID: NCT06426004 Not yet recruiting - Clinical trials for Normal Pressure Hydrocephalus

Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland

NPH
Start date: April 1, 2025
Phase: N/A
Study type: Interventional

The study aims to estimate Normal Pressure Hydrocephalus (NPH) prevalence and evaluate health equity gaps in Baltimore and Maryland based on zip codes and race, with a focus on the Black community. Interventions will include educational elements about NPH and three layers targeting patients, Primary Care Providers, and community health workers to enhance care access. Short-term outcomes will measure referrals to specialists, while long-term outcomes will assess healthcare utilization. The study aims to identify and reduce racial disparities in NPH care access, informing intervention strategies for NPH and other surgical areas.

NCT ID: NCT05562596 Not yet recruiting - Clinical trials for Cognitive Impairment

Normal Pressure Hydrocephalus Biomarkers Investigation

NORPHY
Start date: October 30, 2022
Phase:
Study type: Observational

Normal Pressure Hydrocephalus (NPH) is a clinical condition that induces cognitive deterioration that can be reverted, at least in part, by introducing ventricular-peritoneal diversion controlled by a miniaturized valve system. Mechanisms involved in such an improvement of cognitive function after liquor diversion are unknown. Oxysterols are a family of cholesterol-related compounds having diverse biological functions. Among others, they are involved in cholesterol homeostasis in the brain and are detectable in liquor, potentially impacting neurodegeneration. NPH is an ideal clinical model to study oxysterol distribution in liquor before and after ventricular-peritoneal diversion.