Development of 3T Magnetic Resonance Research Methods for NIA Studies

Status Recruiting

Clinical Trial Summary

Background: - Magnetic resonance imaging (MRI) studies provide important information on the structure and function of various body systems, including the brain, muscles, joints, heart, and blood vessels. Scientific applications of MRI scans often use techniques that need to be modified or refined before they are used in clinical studies. To develop and modify these techniques for the new Philips 3T Achieva whole-body MRI scanner, researchers are interested in conducting trial MRI scans on healthy individuals and individuals with conditions that require imaging studies. Objectives: - To conduct preliminary trials of the 3T MRI facility to develop and refine MRI scanning procedures. Eligibility: - Individuals at least 18 years of age who are able to have magnetic resonance imaging. Design: - Participants will be screened with a full medical history and physical examination, as well as blood and urine tests. - Participants will have an MRI scan using the 3T scanner. Some scans may require the use of a contrast agent or radiotracer, which is a small amount of radioactive substance that will be injected before the start of the scan. Some participants may be asked to perform tasks of thinking and movement while in the scanner, in order to test the procedures required for a functional MRI scan. - No treatment will be provided as part of this protocol.

Clinical Trial Description

Study Description: The purpose of this protocol is to permit use of the magnetic resonance imaging (MRI) facility for the development and refinement of MRI and spectroscopy (MRIS) scanning procedures. The information obtained through these methodological assessments will be essential future clinical research investigations conducted through the NIA under specific protocols. Additionally, this data can be utilized in already approved NIA studies for comparison purposes. Objectives: Primary Objective: To develop and refine specific MR imaging and spectroscopy methods. Secondary Objectives: To allow pilot tests of procedures for development and refinement of motor or cognitive activation paradigms. Endpoints: Development of noninvasive MR biomarkers to assess longevity, healthy longevity, physical disability, cognitive impairment, and frailty. ;

Study Design

Related Conditions & MeSH terms

Normal Physiology

Clinical Trial Details

NCT number	NCT01324206
Study type	Observational
Source	National Institutes of Health Clinical Center (CC)
Contact	Sarah Park, R.N.
Phone	(410) 350-7315
Email	sarah.park@nih.gov
Status	Recruiting
Phase
Start date	November 3, 2008

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.