Normal Pancreatic Tissue Clinical Trial
Official title:
Could Quantitative And Qualitative EUS-Elastography Results Be Affected By The Compression Rate And The Diameter Of The Region Of Interest (ROI)?
Endoscopic ultrasonography is considered the most accurate methods for the diagnosis and
staging of chronic inflammatory and neoplastic pancreatic diseases. Differential diagnosis
of solid pancreatic masses, however, remains a challenge and endoscopic ultrasound-guided
fine needle aspiration is necessary. Recently, Endoscopic ultrasound elastography has been
introduced as an alternative method to evaluate tissue stiffness of solid pancreatic masses,
being an index of tissue elasticity, which may be related to histopathology features (hard
tissue = blue = neoplastic and soft tissue = red-yellow-green = non-neoplastic). However,
recently publications show different results using elastography. Moreover, a lack of data in
Endoscopic ultrasound-elastography exist regarding the compression rate of the probe and the
diameter of the region of interest under analysis in previously studies that by physics
could affect the tissue elasticity.
Based on the hypothesis that elastography could be affected by compression rate of the probe
and the diameter of the region of interest analyzed the present study aimed to evaluate the
quantitative (strain ratio) and qualitative endoscopic ultrasound-elastography results
determined by the compression rate of the probe (measured by the curve of compression in the
second generation of elastography) and the diameter of the region of interest in normal
pancreatic tissue.
prospective study performed in patients undergoing for upper-endoscopic ultrasound from October 31-to end of November 2013. Endoscopic ultrasound-elastography was performed using linear Pentax-EUS and "Hitachi-Avius". The quantitative-strain ratio and qualitative endoscopic ultrasound-elastography was measured in the body of the pancreas taking in consideration the curve of the compression rate of the probe high: +0.4, middle: 0, low: -0.4 in the largest and smaller region of interest diameters. Analysis for qualitative elastography was obtained by the predominant color of the pancreatic area studied. Pictures where recorded and quantitative strain ratio data were calculated comparing endoscopic ultrasound-elastography of pancreatic tissue with soft tissue (normal mucosal layer: red). Finally, a comparative analysis was performed between the results with the mean normal value for quantitative strain ratio previously published for normal pancreatic tissue, and between the different compression rates of the probe. ;
Observational Model: Case-Only, Time Perspective: Prospective