Nonalcoholic Fatty Liver Disease Clinical Trial
Official title:
A Phase 1B, Repeated Dose Study, to Evaluate the Safety, PD and PK Profile of CM-101 in NAFLD Patients With Normal Liver Function Tests and Stable NAFLD/NASH Patients With NAFLD Activity Score (NAS) < 3-The SPARK Study
A two-part study for NAFLD subjects with normal liver functions and in general good health to be treated with CM-101 or matching placebo and NAFLD/NASH Activity Score (NAS) < 3 that are in general good health and have normal liver functions to be treated with CM-101.
This study is designed to assess the safety and preliminary pharmacodynamics of repeated administrations of CM-101 in two subject populations. The objective of part one of this study is to demonstrate that repeated treatment with CM-101 will be safe and well tolerated in NAFLD subjects that have normal liver functions and are in general good health. A second expansion part will be carried out that will include patients with NAFLD/NASH Activity Score (NAS) < 3 that are in general good health and have normal liver functions. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06138327 -
A Study of BMN 255 in Participants With Non-Alcoholic Fatty Liver Disease And Hyperoxaluria
|
Phase 1 | |
| Completed |
NCT01045499 -
LAGB as a Treatment for Morbid Obesity in Adolescents
|
N/A | |
| Completed |
NCT03674476 -
An Investigational Study to Evaluate Experimental Medication BMS-986036 in Participants With Different Levels of Kidney Function
|
Phase 1 | |
| Not yet recruiting |
NCT05495139 -
Gastric Bypass Stent Small-Sample-Size Study For Nonalcoholic Fatty Liver Disease
|
N/A | |
| Completed |
NCT04988204 -
Diabetes Prevention Program for the Treatment of Nonalcoholic Fatty Liver Disease
|
N/A | |
| Recruiting |
NCT04369521 -
Evaluation of the Effects of a Low Free Sugar Diet in Patients With Nonalcoholic Fatty Liver Disease
|
N/A | |
| Completed |
NCT01934777 -
Efficacy and Tolerance of Treatment With DHA, Choline and Vitamin E in Children With Non-alcoholic Steatohepatitis
|
Phase 3 | |
| Enrolling by invitation |
NCT00983463 -
Abundance and Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)
|
||
| Recruiting |
NCT00658164 -
Effect of Iron Depletion by Phlebotomy Plus Lifestyle Changes vs. Lifestyle Changes Alone on Liver Damage in Patients With Nonalcoholic Fatty Liver Disease With Increased Iron Stores
|
Phase 3 | |
| Recruiting |
NCT02148471 -
Fatty Acids, Genes and Microbiota in Fatty Liver
|
N/A | |
| Completed |
NCT03656744 -
A Study of HTD1801 in Adults With Nonalcoholic Steatohepatitis (NASH) and Type 2 Diabetes Mellitus (T2DM)
|
Phase 2 | |
| Not yet recruiting |
NCT01735799 -
THE ASSOCIATION BETWEEN FATTY LIVER (NAFLD) DISEASE AND PCOS
|
N/A | |
| Completed |
NCT01446276 -
Long-term Investigation of Resveratrol on Fat Metabolism in Obese Men With Nonalcoholic Fatty Liver Disease
|
N/A | |
| Completed |
NCT00930384 -
A Case Control Study Evaluating the Prevalence of Non-Alcoholic Fatty Liver Disease Among Patients With Psoriasis
|
N/A | |
| Recruiting |
NCT02469272 -
Fecal Microbiota Transplantation (FMT) in Nonalcoholic Steatohepatitis(NASH). A Pilot Study
|
Phase 1 | |
| Completed |
NCT02132780 -
Autonomic Dysfunction in Non-Alcoholic Fatty Liver Disease
|
N/A | |
| Terminated |
NCT01355575 -
Rifaximin in Fatty Liver Disease
|
Phase 4 | |
| Completed |
NCT01399645 -
Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes
|
Phase 2 | |
| Completed |
NCT01210989 -
Trial of Hepaguard® in Adults With Nonalcoholic Steatohepatitis
|
N/A | |
| Completed |
NCT03434613 -
Phase IV Study to Evaluate the Effects of Statin Monotherapy or Statin / Ezetimibe Combination Therapy on Hepatic Steatosis in Patients With Hyperlipidemia and Nonalcoholic Fatty Liver Disease
|
Phase 4 |