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Bacille Calmette-Guerin (BCG) Vaccine for Immune Protection Against Infections

Cystic Fibrosis Clinical Trial

Official title:
Effects of BCG Vaccine on the Immune System of Individuals With Cystic Fibrosis, Non-Cystic Fibrosis Bronchiectasis, and Healthy Volunteers

Clinical Trial Summary

This is pilot study of the immunologic effects of intradermal Bacille Calmette-Guerin (BCG) vaccination of adults with cystic fibrosis (CF), non-CF bronchiectasis (NCFB), and healthy volunteers.

Clinical Trial Description

This single-site, open-label clinical trial to investigate the immune effects of BCG vaccination in adults with cystic fibrosis, non-cystic fibrosis bronchiectasis and healthy volunteers by measuring pre and post vaccination immune responses, BCG uptake and protection against infections, including nontuberculous mycobacteria (NTM). This study will also gather data on study feasibility, tolerability, and safety. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04884308
Study type Interventional
Source Johns Hopkins University
Contact
Status Completed
Phase Phase 2
Start date April 28, 2021
Completion date December 30, 2023
View Details
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