Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients

Non Surgical Periodontal Therapy Clinical Trial

Official title:

Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06270004
• Other study ID #: nonsurgical periodontal
• Status: Not yet recruiting
• Phase: N/A
• Start date: March 1, 2024
• Est. completion date: December 1, 2024

Study information

• Verified date: February 2024
• Source: University of Baghdad
• Contact: Aqeel Ali, baccalaureus
• Phone: +96407705518935
• Email: aqeel.ali2205[@]codental.uobaghdad.edu.iq
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

1. To assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months) .

2. To evaluate the response of clinical periodontal parameters ( plaque index ,bleeding on probing ,probing pocket depth ,clinical attachment loss)following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals (one month and three months)

Description:

the study include nonsurgical periodontal therapy for smoker and non smoker patients with unstable periodontitis and evaluate the clinical periodontal parameters ( plaque index, bleeding on probing , probing pocket depth ,clinical attachment loss) and assess the alteration in the level of salivary osteopontin (OPN), osteonectin(ON) and histatin-1 following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals(one month and three months)

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 30
• Est. completion date: December 1, 2024
• Est. primary completion date: November 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• participants will be systemically healthy without history of any systemic diseases.

• hadn't underwent periodontal treatment during the previous 6 months and not taken medication during the previous 3 months.

• present with at least 20 teeth, those who only diagnosed with 4-6 mm probing pocket depth, generalized ,unstable periodontitis who had bone loss > 30% , probing probing pocket depth at =4mm . Periodontitis cases were defined if clinical attachment loss was detected at =2 non- adjacent teeth or when buccal (facial) showed clinical attachment loss =3mm associated with probing pocket depth >3mm at = 2 teeth .

• The patients in the smokers group will be current smokers ( cigarette smokers) with smoking habit for over 3 years

Exclusion Criteria:

• Subjects have any intraoral plaque retentive factors such as those wearing partial denture, crown and bridges, and orthodontic appliances ,furcation involved teeth, overhang filling, tooth anomaly.

• receiving antibiotic therapy during the previous 3 months.

• those with systemic diseases such as diabetes mellitus, cardiovascular or renal diseases, etc…., pregnant or lactating women, not willing to participate or continue to conduct the study.

Related Conditions & MeSH terms

• Non Surgical Periodontal Therapy
• Periodontitis

Intervention

Other:
• nonsurgical periodontal therapy
sonic scaler for scaling and polishing. Graces curettes numbers(1-2,3-4,5-6,7-8,9-10,11-12,13-14)for root surfaces debridement(RSD), instructions and motivation for dental arch

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Baghdad

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.	salivary concentration of osteopontin between smoker and nonsmoker unstable periodontitis patients following NSPT at different time intervals.	baseline, one month and three months
Secondary	Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients.	salivary concentration of osteonectin between smoker and nonsmoker unstable periodontitis patients following NSPT at different time intervals .	baseline, one month and three months
Secondary	Effect of nonsurgical periodontal therapy(NSPT) on salivary biomarkers related to bone turnover in smoker and nonsmoker periodontitis patients	salivary concentration of histatin1 between smoker and nonsmoker unstable periodontitis patients following NSPT at different time intervals.	baseline, one month and three months