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Clinical Trial Summary

Aim of the study is to investigate the efficacy and safety of Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) in NSCLC patients in a phase II clinical trial.


Clinical Trial Description

Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a personalized immunotherapy. In patients with advanced Non-Small Cell Lung Cancer (NSCLC), a phase I clinical trial has investigated TIL-ACT in patients who progressed during ICI-treatment. For TIL-ACT, tumor-specific T cells are expanded from excised tumor samples and stimulated in cell culture with interleukin-2 (IL-2). The resulting autologous TILs are then re-infused to the patient after a non-myeloablative lymphodepleting chemotherapy with cyclophosphamide and fludarabine. Activation of TILs in the patient is then supported by IL-2 administration. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06455917
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact David König, MD
Phone +41 61 265 5074
Email david.koenig@usb.ch
Status Not yet recruiting
Phase Phase 2
Start date July 2024
Completion date December 2029

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