| Eligibility |
Inclusion Criteria:
1. voluntary participation in clinical research; Fully understand and Informed the study
and sign the Informed Consent Form (ICF); Be willing to follow and be able to complete
all trial procedures.
2. Age =18 years old and =75 years old when signing ICF.
3. histologically or cytologically confirmed advanced or postoperative recurrent
non-small cell lung cancer (AJCC 8th edition).
4. STK11 mutations were detected by NGS, and no other sensitive mutations could be
targeted therapy (including EGFR, ALK, ROS1, RET, c-Met, HER2, BRAF gene
rearrangement, fusion, amplification, and skipping).
5. The patient had not received systemic antitumor therapy.
6. Patients who had received one prior chemotherapy regimen were allowed, regardless of
whether chemotherapy was administered before, after, or concurrently with targeted
therapy.
7. Patients receiving adjuvant or neoadjuvant therapy were allowed if
adjuvant/neoadjuvant therapy had been completed at least 12 months before diagnosis of
advanced or postoperative recurrent NSCLC.
8. The interval between the end of previous nonsystemic antitumor therapy and the start
of study medication had to be 4 weeks or more. Treatment-related AE recovered to CTCAE
4.03= grade 1 (except grade 2 alopecia).
9. have at least one measurable target lesion as assessed by the investigator according
to iRECIST requirements within 4 weeks before enrollment.
10. If available, patients can provide eligible tumor tissue for PD-L1 expression level
measurement.
11. an ECOG PS score of 0 or 1 within 7 days before the first dose of study medication.
12. predicted survival time =12 weeks (3 months).
13. had good major organ function, defined as meeting the following criteria, and had not
received blood transfusions, albumin, recombinant human thrombopoietin, or
colony-stimulating factor (CSF) within 14 days before the first dose of study
medication.
14. Female patients must meet one of the following conditions:
(1)menopause, defined as absence of menses for at least 1 year and no confirmed cause other
than menopause, or (2) having undergone sterilization (removal of ovaries and/or uterus) 3)
be fertile, provided that: Patients had to have a negative serum pregnancy test within 7
days before randomization and agree to use contraception with an annual failure rate of <1%
or to abstain from heterosexual intercourse for at least 120 days from the date of written
informed consent until the last dose of trial drug was administered. At least 150 days
after the last dose of chemotherapy) (contraceptive methods with an annual failure rate of
<1% include bilateral tubal ligation, male sterilization, proper use of
ovulation-suppressing hormonal contraceptives, hormone-releasing intrauterine devices, and
copper intrauterine devices or condoms), and Do not breastfeed.
15.Male patients had to agree to either abstain from sex (avoid heterosexual intercourse)
or to use contraception, as specified by either abstinence or use of condoms to prevent
exposure of the drug to the embryo during chemotherapy (paclitaxel/pemetrexed/carboplatin)
for the duration of treatment with a woman of reproductive age or a pregnant partner and
for at least 150 days after the last dose of chemotherapy. Regular abstinence (e.g.,
calendar day, ovulation, basal body temperature, or postovulatory methods of contraception)
and in vitro ejaculation are ineligible methods of contraception.
Exclusion Criteria:
1. received systemic therapy for advanced NSCLC within 4 weeks after enrollment;
2. the subjects had a history or concurrent history of other malignant tumors (except
3.cured basal cell carcinoma of the skin and carcinoma in situ of the cervix).
candidates for or prior recipients of organ or bone marrow transplantation.
4.uncontrollable pleural, pericardial, or ascites with appropriate interventions.
5.subjects with clinically symptomatic CNS metastases (e.g., brain edema, need for hormonal
intervention, or progression of brain metastases). Patients who had received previous
treatment for brain or meningeal metastases were eligible if they had been clinically
stable (on MRI) for at least 2 months and had stopped systemic hormone therapy (at a dose
of >10mg per day of prednisone or other iso-efficacy hormones) for more than 2 weeks.
6.spinal cord compression that cannot be cured by surgery and/or radiotherapy. 7. have a
history of hemoptysis (> 50ml/day) within 3 months before screening; Or clinically
significant bleeding symptoms or a definite tendency to bleed.
8. received definitive thoracic radiotherapy within 28 days before enrollment; Subjects who
received palliative radiotherapy to a bone lesion outside the chest within 2 weeks before
receiving the first dose of study drug.
9. severe unhealed wound ulcers or fractures, or major surgery within 28 days before
randomization or expected to undergo major surgery during the study period.
10.Any unstable systemic disease: These included, but were not limited to, active pulmonary
tuberculosis, active infection, unstable angina, cerebrovascular accident or transient
ischemic attack (within 6 months before screening), myocardial infarction (within 6 months
before screening), and congestive heart failure (New York Heart Association [NYHA] class =
2 Grade II), severe cardiac arrhythmias requiring medical therapy, and hepatic, renal, or
metabolic disorders 11. poorly controlled hypertension (defined as systolic blood pressure
(BP) =160 mmHg and/or diastolic blood pressure =100 mmHg) with a history of hypertensive
crisis or hypertensive encephalopathy.
12. clinically significant hemoptysis (> 50ml/day) within 3 months before enrollment; Or
clinically significant bleeding symptoms or a clear bleeding tendency, such as
gastrointestinal bleeding, hemorrhagic gastric ulcer, baseline fecal occult blood ++ or
above, or large vessel vasculitis; Arterial/venous thrombotic events occurred within 12
months before enrollment, such as cerebrovascular accident, deep vein thrombosis, and
pulmonary embolism.
13. patients with CTCAE 4.03 peripheral neuropathy grade =2.
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