| Eligibility |
Inclusion Criteria:
1. Patients must be able to understand the nature of the trial and provide a signed and
dated informed consent form prior to screening.
2. Aged at least 18 years old when sign ICF.
3. Histological or cytological confirmed locally advanced or metastatic NSCLC.
4. Patients must exhibit Eastern Cooperative Oncology Group (ECOG) performance status 0 -
1 at ICF signature with no deterioration over the previous 2 weeks.
5. Predicted life expectancy = 12 weeks.
6. Patients with brain metastasis (BM) can only be enrolled under the condition that BM
is previously treated and stable e.g. no evidence of progression for at least 2 weeks
after CNS-directed treatment as ascertained by clinical examination and brain imaging
(magnetic resonance image [MRI] or computed tomography [CT] scan) during the screening
period), neurologically asymptomatic and not require corticosteroid treatment.
7. Adequate organ system functions, as outlined below
- Absolute neutrophil count (ANC) = 1.5 x 109/L
- Absolute lymphocyte count = 0.8 x 109/L
- Platelets = 100 x 109/L
- Hemoglobin = 9 g/dL
- Total bilirubin = 1.5 x ULN if no liver metastases or = 3 x ULN in the presence
of documented Gilbert's Syndrome (unconjugated hyperbilirubinemia) or liver
metastases
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) = 2.5 x ULN
if no liver involvement or = 5 x ULN with liver involvement
- Creatinine = 1.5 x ULN, or measured creatinine clearance = 50 mL/min as
calculated by the Cockcroft-Gault method
- International normalized ratio (INR) = 1.5 x ULN and activated partial
thromboplastin time (APTT) = 1.5 x ULN;
- Serum amylase = 1.5 x ULN and serum lipase = 1.5 x ULN
8. Male subjects with a female partner who intend to have children should use barrier
contraception (e.g. condom) during their participation in the clinical study until 6
months after the last dose. Male subjects should not donate sperm during the clinical
study until 6 months after the last dose. If the male subject has fertility
requirements, it is recommended that sperm be frozen prior to the start of the
clinical study.
9. Female subjects should use contraception at screening until 6 weeks after the last
dose of DZD9008 or 3 months after the last dose of AZD4205, whichever is later, should
not be breastfeeding and should have a negative pregnancy test (blood or urine ß-HCG)
at the time of screening.
Part A specific inclusion criteria:
1. Subjects should harbour any type of EGFR mutation.
2. Subjects should have progressed on, or be intolerant of prior standard systemic
therapy for metastatic/locally advanced disease.
Part B specific inclusion criteria:
1. Subjects must have documented EGFR sensitizing mutation from a local certified
laboratory.
2. Subjects should have progressed on, or be intolerant of prior standard systemic
therapy for metastatic/locally advanced disease.
3. Patient must have measurable disease according to RECIST 1.1: At least one lesion, not
previously irradiated, that can be accurately measured at baseline as = 10 mm in the
longest diameter (except lymph nodes which must have short axis =15 mm) with computed
tomography (CT) or magnetic resonance imaging (MRI) and which is suitable for repeated
measurement.
4. Agree and be willing to provide an adequate amount of the required tumor tissue for
exploratory studies.
Exclusion Criteria:
1. Treatment with any of the followings:
- Prior treatment with any onco-immunotherapy (e.g. PD-1) within 4 weeks before the
first administration of IP.
- Any cytotoxic chemotherapy, or other anticancer drugs from a previous treatment
regimen within 2 weeks before the first administration of IP.
- Radiotherapy within 2 weeks of the first dose or have not recovered from
radiotherapy-related toxicity May receive palliative radiotherapy other than
chest and brain, stereotactic radiosurgery and stereotactic body radiation
therapy within 1 week prior to first dose a limited field of radiation for
palliation within 1 week of the first administration of IP.
- Patients currently receiving (or unable to stop using) medications known to be
potent inhibitors or inducers of CYP3A or herbal supplements within 2 weeks
before the first administration of IP.
- Patients should avoid eating food known to be inhibitors of CYP3A such as
grapefruit and Seville oranges (and other products containing these fruits, e.g.,
grapefruit juice or marmalade) within 2 weeks before the first administration of
IP and 2 weeks after the therapy.
- Drugs that prolong the QT interval need to be discontinued before the start of IP
- Major surgery (excluding biopsy) within 4 weeks before the first administration
of IP, or expect to have major surgery during study.
- Treatment with any investigational drug (or unable to stop using) within 4 weeks
before the first administration of IP
2. Spinal cord compression or leptomeningeal metastasis.
3. Prior malignancy within 2 years requires active treatment, except for adequately
treated basal cell skin carcinoma, in situ cervical carcinoma, or other cancer type
which has been disease free for > 2 years with life expectancy >2 years
4. Any unresolved toxicities from prior therapy greater than CTCAE grade 1 at the time of
starting IP with the exception of alopecia.
5. History of stroke or intracranial haemorrhage within 6 months before the first
administration of IP.
6. As judged by the investigator, any evidence of severe or uncontrolled systemic
diseases, including uncontrolled hypertension and active bleeding diatheses (e.g.,
hemophilia, Von Willebrand disease).
7. Presence of persistent or active infection, including but not limited to:
- Active or latent tuberculosis
- Active herpes simplex, herpes zoster infection
- COVID-19
- active HBV, HCV, HIV infection
8. Any of the following cardiac abnormal and disease:
- resting corrected QT interval (QTc) > 470 msec
- Any clinically significant abnormalities in rhythm, conduction or morphology of
resting ECG, e.g., complete left bundle branch block, third degree heart block,
and second-degree heart block, PR interval > 250 msec
- Any factors that increase the risk of QTc prolongation, such as heart failure,
hypokalemia, congenital long QT syndrome, family history of long QT syndrome or
unexplained sudden death under 40 years of age in first degree relatives or any
concomitant medication known to prolong the QT interval
- Prior history of atrial fibrillation except prior drug treatment related and
recovered
- Prior history of myocardial infarction, congestive heart failure, arrhythmias
that are poorly controlled by medication
- LVEF < 55% accessed by ECHO
9. Past medical history of interstitial lung disease, drug-induced interstitial lung
disease, radiation pneumonitis which required steroid treatment, or any evidence of
clinically active interstitial lung disease, immunotherapy-induced immune pneumonitis.
10. Significant pulmonary function impairment (i.e. pulmonary function test showing FEV1
and DLCO < 60% of expected values).
11. Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to
swallow the formulated product or previous significant bowel resection that would
preclude adequate absorption of IP.
12. Receiving live vaccines within 2 weeks before the first administration of IP.
13. Women who are pregnant or breast feeding.
14. Involvement in the planning and conduct of the study (applies to Dizal staff or staff
at the study site).
15. Judgment by the investigator that the patient should not participate in the study if
the patient is unlikely to comply with study procedures, restrictions and
requirements.
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