Tissue Eosinophils in Non-Small Cell Lung Cancer (the TEN Study)

Non-small Cell Lung Cancer Clinical Trial

— TEN  

Official title:

Tissue Eosinophils in Non-Small Cell Lung Cancer (the TEN Study)

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05537701
• Other study ID #: 2022/158
• Status: Active, not recruiting
• Start date: October 3, 2022
• Est. completion date: March 31, 2027

Study information

• Verified date: January 2024
• Source: Centre Hospitalier Universitaire de Liege
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The primary objective is to describe eosinophil infiltration in resected (early stage) NSCLC.

Secondary objectives are:

• to investigate the correlation of T-Eos and B-Eos in the aforementioned patient population;

• to investigate the correlation between T-Eos and overall & disease-free survival;

• to investigate the localization of T-Eos (periphery vs. center of the tumor lesions).

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 316
• Est. completion date: March 31, 2027
• Est. primary completion date: March 31, 2027
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Resected, early stage NSCLC between 01-01-2015 and 30-04-2022 with available tumour tissue

Exclusion Criteria:

• Inclusion in a clinical study contraindicating enrollment in the present study

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• Lung Neoplasms
• Non-small Cell Lung Cancer

Locations

Country	Name	City	State
Belgium	CHU de Liege	Liège

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Liege

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of tumor associated tissue eosinophilia by immunohistochemistry and computerised quantification		October 2022
Secondary	to investigate the correlation of tissue (T)-Eos and blood (B)-Eos in the aforementioned patient population	Tissue and blood eosinophil correlation	December 2022
Secondary	to investigate the correlation between T-Eos and overall & disease-free survival	overall and disease-free survival	December 2022
Secondary	to investigate the localization of T-Eos (periphery vs. center of the tumor lesions)	tissue eosinophil localisation	December 2022