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Clinical Trial Summary

This study is phase II, open label, clinical trial of durvalumab to identify immune dynamics in operable non-small cell lung cancer.

Clinical Trial Description

In this study, the investigators plan to administer neoadjuvant durvalumab and adjuvant durvalumab to the operable NSCLC patients (resectable stage IIA~IIIB) regardless of PD-L1 status. Durvalumab 1500mg IV will be administered once prior to surgery. Within 1-8 weeks after completion of durvalumab, patients will undergo surgery. Regardless of MRD status, patients will receive adjuvant treatment of durvalumab 1500mg IV q3 weeks with SoC platinum-based chemotherapy for a total of 4 cycles. ** Adjuvant chemotherapy will be based on standard of care treatment: navelbine 20mg/m2 (D1, 8) and cisplatin 80mg/m2 (D1) (q3w x 4 cycles). Thereafter, patients will be administered with adjuvant durvalumab 1500mg IV q4 weeks for 10 cycles ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05206812
Study type Interventional
Source Yonsei University
Contact Hye Ryun Kim
Phone 82-2-2228-8125
Status Not yet recruiting
Phase Phase 2
Start date March 2022
Completion date December 2025

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