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Clinical Trial Summary

This study is a single arm, open-label, intravenous infusion of Anti- Epidermal growth factor receptor (EGFR) Chimeric Antigen Receptor (CAR) T cells modified by C-X-C Chemokine receptor type 5 (CXCR 5) in patients with advanced adult non-small cell lung cancer (NSCLC).


Clinical Trial Description

In this study, the dose(number of cells by body weight) and time of infusion should be recorded in detail according to the dosage of slope climbing and single infusion. The safety of chimeric antigen receptor T(CAR-T) cells treatment was evaluated by observing the adverse events after cell therapy. The effectiveness of CAR-T treatment was initially assessed compared with the results of the patient's own previous standard treatment plan. Blood was collected before and within 12 months after infusion to detect the number and activity of CAR-T cells and evaluate the pharmacokinetic characteristics of CAR-T cells. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05060796
Study type Interventional
Source Second Affiliated Hospital of Guangzhou Medical University
Contact Zhenfeng Zhang, MD, PhD
Phone 0086-020-39195966
Email zhangzhf@gzhmu.edu.cn
Status Recruiting
Phase Early Phase 1
Start date September 1, 2019
Completion date November 1, 2034

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