Analysis of Driver Gene Mutation in Early Stage Non-small Cell Lung Cancer

Non-small Cell Lung Cancer Clinical Trial

Official title:

Molecular Metastasis in Lymph Nodes is Associated With Survival of Patients With Stage I NSCLC

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04266691
• Other study ID #: LN-OMs
• Status: Completed
• Start date: January 2009
• Est. completion date: June 2019

Study information

• Verified date: February 2020
• Source: Zhejiang Cancer Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Analysis of driver gene variation in early stage non-small cell lung cancer

Description:

Fluorescence quantitative polymerase chain reaction (PCR) was used to detect the variation of driver gene in regional lymph nodes of early stage non-small cell lung cancer (NSCLC), and to analyze the relationship between the variation and disease recurrence and survival prognosis. evaluate the effect of the variation of driving gene in lymph nodes of early stage NSCLC on prognosis, identify the high-risk factors that promote the recurrence and metastasis of early stage tumor. so as to improve the diagnosis and treatment path of lung cancer, provide important pathological basis for the clinical diagnosis and treatment of early stage non-small cell lung cancer, enable patients to receive more accurate treatment, and improve their survival prognosis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 237
• Est. completion date: June 2019
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Female or male, 18 years of age or older

2. Histologically or cytologically proven diagnosis of early stage NSCLC

3. The lesion was completely resected by radical surgery

4. Able to get tumor tissue sample

5. Complete information of clinicopathological , survival, recurrence and metastasis can be obtained through follow-up

Exclusion Criteria:

1. Combine with other tumor type

2. The investigator judges the situation that may affect the clinical search process and results

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• Lung Neoplasms
• Non-small Cell Lung Cancer

Intervention

Other:
• nonIntervention
nonIntervention

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Zhejiang Cancer Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Driver gene mutation frequency of early stage NSCLC	Observe the driver gene mutation frequency in regional lymph nodes of early stage non-small cell lung cancer	2019
Primary	Correlation of Clinicopathological characteristics and driver gene mutation in regional lymph nodes of early stage NSCLC	Analyze the correlation between driver gene mutation and clinicopathological features in regional lymph nodes of early stage NSCLC	2019
Primary	Correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC	Observe the correlation between driver gene mutation and survival prognosis in regional lymph nodes of early stage NSCLC	2019