Non-small Cell Lung Cancer Clinical Trial
Official title:
A Prospective Phase Ⅱ Study of Split-course Chemoradiotherapy For Locally Advanced None-small Cell Lung Cancer
This Phase II study is to determine the efficacy of split-course irradiation with concurrent chemotherapy in locally advanced none-small cell lung cancer patients.
This Phase II study is to determine the efficacy of split-course chemoradiotherapy(CCRT) in
locally advanced non-small cell lung cancer.
Patients receive four cycles of weekly docetaxel(25mg/㎡) and nedaplatin(25mg/㎡), each of 1
day's duration, combined with split-course thoracic radiotherapy of 51 Gy/17 fractions and
15-18 Gy/5-6 fractions administered in the first and second courses, respectively, with about
one-month break. The primary endpoint is progression-free survival, which is calculated from
the start of RT to the first identification of disease progression or death. Progression-free
survival will be calculated using the Kaplan-Meier method. Toxicities will be graded
according to CTCAE V.4.0.
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