Non-small Cell Lung Cancer Clinical Trial
Official title:
A Phase II Clinical Trial to Investigate Efficacy and Safety of Apatinib as a Single Agent in RET-fusion Gene Positive Non-small Cell Lung Cancer Who Failed to Previous Treatment.
RET fusions are present in 1% to 2% of unselected population of non-small cell lung cancer (NSCLC). Existing US Food and Drug Administration-approved inhibitors of RET tyrosine kinase show promising therapeutic effects in a non-small cell lung cancer patients. Apatinib is an oral multi-kinase inhibitors including RET fusions. This study is designed to evaluate the safety and tolerability of Apatinib in patients with RET fusion positive advanced NSCLC.
To observe objective response rate (ORR) of apatinib in RET fusion positive pre-treated
advanced NSCLC.
To observe Progression free survival （PFS）. To assess the overall survival (OS). To assess
safety and tolerability. To evaluate quality of life. To explore the relationship between
biomarkers and the toxicity/efficacy of apatinib.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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