Non-small Cell Lung Cancer Clinical Trial
Official title:
A Phase Ⅱ Randomized Clinical Trial Comparing Vinorelbine-ifosfamide With Gefitinib as Third-line Treatment in Advanced EGFR Gene Mutation Negative Non-small Cell Lung Cancer Patients
In the National Comprehensive Cancer Network (NCCN) guideline for NSCLC, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is recommended as the third-line treatment for EGFR gene mutation negative NSCLC patients who failed to the first-line platinum doublet chemotherapy [i.e. paclitaxel-carboplatin (PC) or gemcitabine-cisplatin (GP)] and the second-line chemotherapy with docetaxel or pemetrexed. But as we know, if patients had no EGFR gene mutation, EGFR-TKI treatment is not effective. The overall survival is short and the objective response rate is low. As for EGFR gene wild type patients with good performance status, besides EGFR-TKI treatment, other first generation cytotoxic drugs i.e. vinorelbine or ifosfamide maybe an alternative treatment. So the purpose of this clinical trial is to compare the effectiveness and safety of vinorelbine-ifosfamide with gefitinib in advanced or metastatic EGFR gene mutation negative NSCLC patients.
Ifosfamide is a first generation cytotoxic drug to treat NSCLC. Phase Ⅱ studies demonstrated
that single-agent ifosfamide administrated by various schedules produces response rates of
15-29%, with media survival times of 5-7 months. Ifosfamide has also been used in various
combination regimens to treat NSCLC, including platinum based and non-platinum regimens. But
in refractory NSCLC patients platinum and some third generation cytotoxic drugs have been
used before. So in this study, ifosfamide is combined with vinorelbine. In previous study,
Masters reported the objective response rate was 40% and the median survival duration was 50
weeks, with a 1-year survival rate of 48% with vinorelbine-ifosfamide regimen [Vinorelbine
15 mg/m2 on days 1-3, and ifosfamide 2.0g/m2 on days 1-3 with granulocyte-colony stimulating
factor (G-CSF) support]. The dose limiting toxicity (DLT) of this regimen is
myelosuppression. In our experience, the regimen of vinorelbine 25mg/m2 d1, d8 and
ifosfamide 1.25g/m2 d1-d3 with Mesna uroprotection is safe in Chinese population and the
objective response rate is about 7% (data not published).
Gefitinib is the first small molecule inhibitor that has directed activity towards EGFR and
has shown appreciable response rates in phase Ⅱ trials of patients with previously treated
advanced NSCLC. In the posterior analysis of Iressa Dose Evaluation in Advanced Lung Cancer
(IDEAL) and IRESSA Survival Evaluation in Lung Cancer (ISEL) trials, the response rate with
gefitinib ranges from 2.6% to 10% in wild-type EGFR gene NSCLC patients.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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