Non-small Cell Lung Cancer Clinical Trial
Official title:
A Phase I-II Evaluation of the Safety and Efficacy of the Oral HSP90 Inhibitor Debio 0932 in Combination With Standard of Care in first-and Second-line Therapy of Patients With Stage IIIb or IV Non-small Cell Lung Cancer-the HALO Study (HSP90 Inhibition And Lung Cancer Outcomes)
Part A of this study will investigate the Maximum Tolerated Dose of Debio 0932 in combination with standard of care chemotherapy for the first- and second-line treatment of advanced NSCLC.
Part A of this study will determine the Maximum Tolerated Dose of Debio 0932 in combination
with cisplatin/pemetrexed and cisplatin/gemcitabine in treatment-naïve patients with Stage
IIIb or IV NSCLC, and with docetaxel in previously treated patients with Stage IIIb or IV
NSCLC.
Escalating doses of Debio 0932 will be given to subsequent patients in combination with
standard doses of these 3 background chemotherapies.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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