A Study of Apatinib in Patients With Advanced Non-squamous and Non-small Cell Lung Cancer

Non-Small-Cell Lung Cancer Clinical Trial

Official title:

A Randomized, Placebo-controlled, Double-blind, Multicenter, Phase II Study of Apatinib as Third Line Treatment in Patients With Advanced Non-squamous and Non-small Cell Lung Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01270386
• Other study ID #: HENGRUI 20101219
• Status: Completed
• Phase: Phase 2
• First received: December 29, 2010
• Last updated: February 9, 2012
• Start date: March 2010
• Est. completion date: September 2011

Study information

• Verified date: February 2012
• Source: Jiangsu HengRui Medicine Co., Ltd.
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor receptor (VEGFR), and it's anti-angiogenesis effect has been viewed in preclinical tests. Phase I study has shown that the drug's toxicity is manageable and the maximum tolerable daily dose is 850 mg. The purpose of this study is to determine whether apatinib can improve progression free survival compared with placebo in patients with advanced non-squamous and non-small cell lung cancer who failed two lines of chemotherapy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 136
• Est. completion date: September 2011
• Est. primary completion date: July 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• = 18 and = 70 years of age

• Histologically or cytologic confirmed advanced non-squamous and non-small cell lung cancer.

• At least one measurable lesion which has not received radiotherapy (larger than 10 mm in diameter by spiral CT scan)

• Have failed for 2 lines of chemotherapy including EGFR-TKI.

• ECOG performance scale 0 - 1.

• Life expectancy of more than 3 months.

• Duration from the last therapy is more than 6 weeks for nitroso or mitomycin

• More than 4 weeks after operation or radiotherapy

• More than 4 weeks for cytotoxic agents or tyrosine kinase inhibitors inhibitors

• Adequate hepatic, renal, heart, and hematologic functions (hemoglobin = 90g/L, platelets = 80×10^9/L, neutrophils = 1.5×10^9/L, total bilirubin within 1.25×the upper limit of normal(ULN), and serum transaminase=2.5×the ULN (If liver metastases, serum transaminase=5×the ULN), serum creatine = 1.5 x ULN, creatinine clearance rate = 50ml/min,

• signed and dated informed consent.Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedure.

Exclusion Criteria:

• Squamous cell carcinoma (including adenosquamous carcinoma, undifferentiated carcinoma); small cell lung cancer (including small cell and non-small cell mixed lung cancer)

• Pregnant or breastfeeding women

• Intercurrence with one of the following: hypertension, coronary artery disease, arrhythmia and heart failure

• Any factors that influence the usage of oral administration

• PT, APTT, TT, Fbg abnormal, Receiving the therapy of thrombolysis or anticoagulation.

• Within 4 weeks before the first use of drugs, occurs pulmonary hemorrhage (= CTCAE class 2) or other parts' hemorrhage (= CTCAE class 3).

• Long-term untreated wounds or fractures.

• Within 6 months before the first treatment occurs artery / venous thromboembolic events, such as cerebral vascular accident (including transient ischemic attack), deep vein thrombosis and pulmonary embolism, etc.

• Application of anticoagulants or vitamin K antagonists such as warfarin, heparin or its analogues; If the prothrombin time international normalized ratio (INR) = 1.5, with the purpose of prevention, the use of small doses of warfarin (1mg orally, once daily) or low-dose aspirin (between 80mg to 100mg daily) is allowed.

• Abuse of alcohol or drugs

• Less than 4 weeks from the last clinical trial

• Treatment with VEGFR, PDGFR, sSRC-TKI before.

• History of any second malignancies within 3 years except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• Lung Neoplasms
• Non-Small-Cell Lung Cancer

Intervention

Drug:
• apatinib
Apatinib 750 mg p.o. once daily
• placebo
placebo p.o. once daily

Locations

Country	Name	City	State
China	Department of Medical Oncology, Cancer Center, Sun Yet-sen University	Guangzhou	Guangdong

Sponsors (2)

Lead Sponsor	Collaborator
Jiangsu HengRui Medicine Co., Ltd.	Sun Yat-sen University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Progression free survival		8 weeks	Yes
Secondary	Overall Survival safety		8 weeks	Yes
Secondary	DCR(Disease control rate)		8 weeks	Yes
Secondary	ORR(objective response rate)		8 weeks	Yes
Secondary	QoL(quality of life)		8 weeks	Yes
Secondary	Number of Participants with Adverse Events as a Measure of Safety and Tolerability		8 weeks	Yes